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Journal article
The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook
Journal of immunology research, v 2020, pp 9470102-14
25 May 2020
PMID: 32537473
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dendritic cells (DC) are key phagocytic cells that play crucial roles in both the innate and adaptive immune responses against the human immunodeficiency virus type 1 (HIV-1). By processing and presenting pathogen-derived antigens, dendritic cells initiate a directed response against infected cells. They activate the adaptive immune system upon recognition of pathogen-associated molecular patterns (PAMPs) on infected cells. During the course of HIV-1 infection, a successful adaptive (cytotoxic CD8(+)T-cell) response is necessary for preventing the progression and spread of infection in a variety of cells. Dendritic cells have thus been recognized as a valuable tool in the development of immunotherapeutic approaches and vaccines effective against HIV-1. The advancements in dendritic cell vaccines in cancers have paved the way for applications of this form of immunotherapy to HIV-1 infection. Clinical trials with patients infected with HIV-1 who are well-suppressed by antiretroviral therapy (ART) were recently performed to assess the efficacy of DC vaccines, with the goal of mounting an HIV-1 antigen-specific T-cell response, ideally to clear infection and eliminate the need for long-term ART. This review summarizes and compares methods and efficacies of a number of DC vaccine trials utilizing autologous dendritic cells loaded with HIV-1 antigens. The potential for advancement and novel strategies of improving efficacy of this type of immunotherapy is also discussed.
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Details
- Title
- The Evolution of Dendritic Cell Immunotherapy against HIV-1 Infection: Improvements and Outlook
- Creators
- Hager Mohamed - Drexel UniversityVandana Miller - Drexel UniversityStephen R. Jennings - Drexel UniversityBrian Wigdahl - Drexel UniversityFred C. Krebs - Drexel University
- Publication Details
- Journal of immunology research, v 2020, pp 9470102-14
- Publisher
- Hindawi Publishing Group
- Number of pages
- 14
- Grant note
- Department of Microbiology and Immunology in the College of Medicine Drexel University Institute for Molecular Medicine and Infectious Disease in the College of Medicine Drexel University P30 MH092177 / Public Health Service, National Institutes of Health through the NIMH Comprehensive NeuroAIDS Center (CNAC) R01 MH110360 / Public Health Service, National Institutes of Health through the National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000541565700001
- Scopus ID
- 2-s2.0-85086546087
- Other Identifier
- 991019168213704721
UN Sustainable Development Goals (SDGs)
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology