Journal article
The Immune Signatures data resource, a compendium of systems vaccinology datasets
Scientific data, v 9(1), pp 635-635
20 Oct 2022
PMID: 36266291
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vaccines are among the most cost-effective public health interventions for preventing infection-induced morbidity and mortality, yet much remains to be learned regarding the mechanisms by which vaccines protect. Systems immunology combines traditional immunology with modern 'omic profiling techniques and computational modeling to promote rapid and transformative advances in vaccinology and vaccine discovery. The NIH/NIAID Human Immunology Project Consortium (HIPC) has leveraged systems immunology approaches to identify molecular signatures associated with the immunogenicity of many vaccines. However, comparative analyses have been limited by the distributed nature of some data, potential batch effects across studies, and the absence of multiple relevant studies from non-HIPC groups in ImmPort. To support comparative analyses across different vaccines, we have created the Immune Signatures Data Resource, a compendium of standardized systems vaccinology datasets. This data resource is available through ImmuneSpace, along with code to reproduce the processing and batch normalization starting from the underlying study data in ImmPort and the Gene Expression Omnibus (GEO). The current release comprises 1405 participants from 53 cohorts profiling the response to 24 different vaccines. This novel systems vaccinology data release represents a valuable resource for comparative and meta-analyses that will accelerate our understanding of mechanisms underlying vaccine responses.
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Details
- Title
- The Immune Signatures data resource, a compendium of systems vaccinology datasets
- Creators
- Joann Diray-Arce - Boston Children's HospitalHelen E R Miller - Fred Hutchinson Cancer Research Center, Seattle, WA, USAEvan Henrich - Fred Hutchinson Cancer Research Center, Seattle, WA, USABram Gerritsen - Yale School of MedicineMatthew P Mulè - University of AtlantaSlim Fourati - Emory University School of MedicineJeremy Gygi - University of New HavenThomas Hagan - University of CincinnatiLewis Tomalin - Icahn School of Medicine at Mount SinaiDmitry Rychkov - University of California, San FranciscoDmitri Kazmin - Jackson LaboratoryDaniel G Chawla - University of New HavenHailong Meng - Yale School of MedicinePatrick Dunn - ImmPort Curation Team, NG Health Solutions, Rockville, MD, USAJohn Campbell - ImmPort Curation Team, NG Health Solutions, Rockville, MD, USAMinnie Sarwal - University of California, San FranciscoJohn S Tsang - Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID NIH Center for Human Immunology, NIH, Bethesda, MD, USAOfer Levy - Broad InstituteBali Pulendran - Stanford University School of MedicineRafick Sekaly - Emory University School of MedicineAris Floratos - Columbia University Irving Medical CenterRaphael Gottardo - University Hospital of LausanneSteven H Kleinstein - Yale School of MedicineMayte Suárez-Fariñas - Icahn School of Medicine at Mount SinaiHuman Immunology Project Consortium (HIPC)Elias El Haddad - College of Medicine (2002-)
- Publication Details
- Scientific data, v 9(1), pp 635-635
- Publisher
- Springer Nature
- Grant note
- U19AI090023 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI118608 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19 AI089992 / NIAID NIH HHS U19AI128913 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) ZIAAI001152 / Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) U19AI128949 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI089992 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) HHSN272201200028C / NIAID NIH HHS U19 AI128949 / NIAID NIH HHS 1ZIAAI001152 / Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) 5U19AI128914 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI118610 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19 AI167903 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000870728600001
- Scopus ID
- 2-s2.0-85140214296
- Other Identifier
- 991020099162704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology