Journal article
The Impact of Racial Disparities on Outcome in Patients With Stage IIIC Endometrial Carcinoma A Pooled Data Analysis
American journal of clinical oncology, v 46(3), pp 114-120
01 Mar 2023
PMID: 36625449
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective:To report the impact of race on clinical outcomes in patients with stage IIIC endometrial carcinoma. Materials and Methods:A retrospective multi-institutional study included 90 black and 568 non-black patients with stage IIIC endometrial carcinoma who received adjuvant chemotherapy and radiation treatments. Overall survival (OS) and recurrence-free survival (RFS) were calculated by the Kaplan-Meier method. Propensity score matching (PSM) was conducted. Statistical analyses were conducted using SPSS version 27. Results:The Median follow-up was 45.3 months. black patients were significantly older, had more nonendometrioid histology, grade 3 tumors, and were more likely to have >1 positive paraaortic lymph nodes compared with non-black patients (all P <0.0001). The 5-year estimated OS and RFS rates were 45% and 47% compared with 77% and 68% for black patients versus non-black patients, respectively (P <0.001). After PSM, the 2 groups were well-balanced for all prognostic covariates. The estimated hazard ratios of black versus non-black patients were 1.613 (P value=0.045) for OS and 1.487 (P value=0.116) for RFS. After PSM, black patients were more likely to receive the "Sandwich" approach and concurrent chemoradiotherapy compared with non-black (P=0.013) patients. Conclusions:Black patients have higher rates of nonendometrioid histology, grade 3 tumors, and number of involved paraaortic lymph nodes, worse OS, and RFS, and were more likely to receive the "Sandwich" approach compared with non-black patients. After PSM, black patients had worse OS with a nonsignificant trend in RFS. Access to care, equitable inclusion on randomized trials, and identification of genomic differences are warranted to help mitigate disparities.
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Details
- Title
- The Impact of Racial Disparities on Outcome in Patients With Stage IIIC Endometrial Carcinoma A Pooled Data Analysis
- Creators
- Tomas Patrich - Rutgers, The State University of New JerseyYaqun Wang - Rutgers, The State University of New JerseyMohamed A. Elshaikh - Ford Motor CompanySimeng Zhu - Henry Ford Canc Inst, Dept Radiat Oncol, Detroit, MI USAShari Damast - Yale UniversityJessie Y. Li - Yale UniversityEmma C. Fields - Virginia Commonwealth UniversitySushil Beriwal - Health NetAndrew Keller - UPMC Hillman Cancer CenterElizabeth A. Kidd - Stanford UniversityMelissa Usoz - Stanford UniversityShruti Jolly - University of Michigan–Ann ArborElizabeth Jaworski - University of Michigan–Ann ArborEric W. Leung - Sunnybrook Health Science CentreNeil K. Taunk - University of PennsylvaniaJunzo Chino - Virginia Commonwealth UniversityAndrea L. Russo - Massachusetts General HospitalJayanthi S. Lea - UPMC Hillman Cancer CenterLarissa J. Lee - Dana-Farber Brigham Cancer CenterKevin V. Albuquerque - UPMC Hillman Cancer CenterLara Hathout - Rutgers, The State University of New Jersey
- Publication Details
- American journal of clinical oncology, v 46(3), pp 114-120
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000937162600005
- Scopus ID
- 2-s2.0-85148679001
- Other Identifier
- 991021897376304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology