Journal article
The Inhibitory Effect of C-Reactive Protein on Bacterial Phosphorylcholine Platelet-Activating Factor Receptor–Mediated Adherence Is Blocked by Surfactant
The Journal of infectious diseases, v 186(3), pp 361-371
01 Aug 2002
PMID: 12134232
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Numerous major bacterial pathogens in the human respiratory tract, including Streptococcus pneumoniae and Haemophilus influenzae express cell-surface phosphorylcholine (ChoP), a ligand for the receptor for platelet-activating factor (rPAF). ChoP is also bound by C-reactive protein (CRP), which, in the presence of complement, may be bactericidal. This study found that CRP can block the attachment of bacteria expressing cell-surface ChoP to host cells. Concentrations of CRP equivalent to those on the mucosal surface of the human airway blocked most adherence of both S. pneumoniae and H. influenzae to human pharyngeal epithelial cells. ChoP-mediated adherence was also reduced in the presence of an rPAF antagonist. The antiadhesive effects of the rPAF antagonist and CRP were not additive, suggesting that CRP activity is specific to the area of adherence mediated by the receptor. The binding of CRP to ChoP and the effect of CRP on adherence were inhibited by human surfactant (primarily ChoP). The antiadhesive effect of CRP may be diminished in the terminal airway, where surfactant is abundant
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Details
- Title
- The Inhibitory Effect of C-Reactive Protein on Bacterial Phosphorylcholine Platelet-Activating Factor Receptor–Mediated Adherence Is Blocked by Surfactant
- Creators
- Jane M. Gould - Pediatrics and GeneticsJeffrey N. Weiser - University of Pennsylvania
- Publication Details
- The Journal of infectious diseases, v 186(3), pp 361-371
- Publisher
- The University of Chicago Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000177111000008
- Scopus ID
- 2-s2.0-0036681670
- Other Identifier
- 991021838144004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology