Journal article
The LDL-C/ApoB ratio predicts major cardiovascular events in patients with established atherosclerotic cardiovascular disease
Atherosclerosis, v 329, pp 44-49
01 Jul 2021
PMID: 34183170
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and aims: The low density lipoprotein cholesterol to Apolipoprotein B (LDL-C/ApoB) ratio is a validated proxy for low density lipoprotein (LDL) particle size that can be easily calculated from a standard lipid/apolipoprotein profile. Whether it is predictive of cardiovascular events in patients with established atherosclerosis is not known and is addressed in the present investigation.
Methods: We determined the LDL-C/ApoB ratio in a cohort of 1687 subjects with established atherosclerosis. Prospectively, major cardiovascular events (MACE) including cardiovascular death, non-fatal myocardial infarction and non-fatal stroke were recorded over a period of 9.9 ± 4.6 years. The study covers >16,000 patient-years.
Results: At baseline, the LDL-C/ApoB ratio was 1.36 ± 0.28 in our cohort. During follow up, a total of 558 first MACE were recorded. The LDL-C/ApoB ratio predicted MACE in univariate Cox proportional hazard analysis (HR 0.90 [0.82–0.98]; p = 0.014); this finding was confirmed after adjustment for age, gender, intensity of statin treatment, hypertension, history of smoking, type 2 diabetes, body mass index and ApoB (HR 0.87 [0.78–0.97]; p = 0.013).
Conclusions: The LDL-C/ApoB ratio is independently predictive of MACE in subjects with established atherosclerosis.
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Details
- Title
- The LDL-C/ApoB ratio predicts major cardiovascular events in patients with established atherosclerotic cardiovascular disease
- Creators
- Heinz Drexel - Drexel University, College of MedicineBarbara Larcher - Private University in the Principality of LiechtensteinArthur Mader - Vorarlberg Institute for Vascular Investigation and TreatmentAlexander Vonbank - Vorarlberg Institute for Vascular Investigation and TreatmentChristine F. Heinzle - Vorarlberg Institute for Vascular Investigation and TreatmentBerthold Moser - Innsbruck Medical UniversityDaniela Zanolin-Purin - Vorarlberg Institute for Vascular Investigation and TreatmentChristoph H. Saely - Vorarlberg Institute for Vascular Investigation and Treatment
- Publication Details
- Atherosclerosis, v 329, pp 44-49
- Number of pages
- 6
- Grant note
- Oesterreichische Nationalbank (501100004061) 14159 / Oesterreichische Nationalbank (http://data.elsevier.com/vocabulary/SciValFunders/501100004061) Institute for Clinical Chemistry Peter Goop Stiftung
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000672117500008
- Scopus ID
- 2-s2.0-85108825577
- Other Identifier
- 991021860761404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease