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Journal article
The Less BOLD, the Wiser: Support for the latent resource hypothesis after traumatic brain injury
Human brain mapping, v 33(4), pp 979-993
17 May 2011
PMID: 21591026
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previous studies of the BOLD response in the injured brain have revealed neural recruitment relative to controls during working memory tasks in several brain regions, most consistently the right prefrontal cortex and anterior cingulate cortices. We previously proposed that the recruitment observed in this literature represents auxiliary support resources, and that recruitment of PFC is not abnormal or injury specific and should reduce as novelty and challenge decrease. The current study directly tests this hypothesis in the context of practice of a working memory task. It was hypothesized that individuals with brain injury would demonstrate recruitment of previously indicated regions, behavioral improvement following task practice, and a reduction in the BOLD signal in recruited regions after practice. Individuals with traumatic brain injury and healthy controls performed the
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‐back during fMRI acquisition, practiced each task out of the scanner, and returned to the scanner for additional fMRI
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‐back acquisition. Statistical parametric maps demonstrated a number of regions of recruitment in the 1‐back in individuals with brain injury and a number of corresponding regions of reduced activation in individuals with brain injury following practice in both the 1‐back and 2‐back. Regions of interest demonstrated reduced activation following practice, including the anterior cingulate and right prefrontal cortices. Individuals with brain injury demonstrated modest behavioral improvements following practice. These findings suggest that neural recruitment in brain injury does not represent reorganization but a natural extension of latent mechanisms that engage transiently and are contingent upon cerebral challenge. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.
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Details
- Title
- The Less BOLD, the Wiser: Support for the latent resource hypothesis after traumatic brain injury
- Creators
- John D. Medaglia - Pennsylvania State UniversityKathy S. Chiou - Psychology Department, Pennsylvania State University, State College, Pennsylvania Department of Neurology, Hershey Medical Center, Hershey, Pennsylvania Department of Radiology, Hershey Medical Center, Hershey, PennsylvaniaJulia Slocomb - Psychology Department, Pennsylvania State University, State College, Pennsylvania Department of Neurology, Hershey Medical Center, Hershey, Pennsylvania Department of Radiology, Hershey Medical Center, Hershey, PennsylvaniaNeal M. Fitzpatrick - Psychology Department, Pennsylvania State University, State College, Pennsylvania Department of Neurology, Hershey Medical Center, Hershey, Pennsylvania Department of Radiology, Hershey Medical Center, Hershey, PennsylvaniaBritney M. Wardecker - Psychology Department, Pennsylvania State University, State College, Pennsylvania Department of Neurology, Hershey Medical Center, Hershey, Pennsylvania Department of Radiology, Hershey Medical Center, Hershey, PennsylvaniaDeepa Ramanathan - Psychology Department, Pennsylvania State University, State College, Pennsylvania Department of Neurology, Hershey Medical Center, Hershey, Pennsylvania Department of Radiology, Hershey Medical Center, Hershey, PennsylvaniaJeffrey Vesek - Psychology Department, Pennsylvania State University, State College, Pennsylvania Department of Neurology, Hershey Medical Center, Hershey, Pennsylvania Department of Radiology, Hershey Medical Center, Hershey, PennsylvaniaDavid C. Good - Psychology Department, Pennsylvania State University, State College, Pennsylvania Department of Neurology, Hershey Medical Center, Hershey, Pennsylvania Department of Radiology, Hershey Medical Center, Hershey, PennsylvaniaFrank G. Hillary - Psychology Department, Pennsylvania State University, State College, Pennsylvania Department of Neurology, Hershey Medical Center, Hershey, Pennsylvania Department of Radiology, Hershey Medical Center, Hershey, Pennsylvania
- Publication Details
- Human brain mapping, v 33(4), pp 979-993
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Grant note
- Social Sciences Research Institute, PSU 4100031293 / Pennsylvania Tobacco Funds 0120090178 / New Jersey Commission on Brain Injury Research
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000301341000018
- Scopus ID
- 2-s2.0-84858288393
- Other Identifier
- 991019296803904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging