Journal article
The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives
Frontiers in psychiatry, v 11, 601519
27 Jan 2021
PMID: 33584368
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction, and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and psychosis on the other side. However, historically, the concepts of arousal and stress have been challenging to define as measurable experimental variables. Divergent efforts to study these subjects have given rise to several disciplines, including neurobiology, neuroendocrinology, and cognitive neuroscience. We discuss technological advancements that chronologically led to our current understanding of the arousal system, focusing on the multifaceted nucleus locus coeruleus. We share our contemporary perspective and the hypotheses of others in the context of our current technological capabilities and future developments that will be required to move forward in this area of research.
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Details
- Title
- The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives
- Creators
- Jennifer A. Ross - Drexel UniversityElisabeth J. Van Bockstaele - Drexel University
- Publication Details
- Frontiers in psychiatry, v 11, 601519
- Publisher
- Frontiers Media
- Grant note
- National Institutes of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000616514200001
- Scopus ID
- 2-s2.0-85100990385
- Other Identifier
- 991021903299704721
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Highly Cited Paper
- Web of Science research areas
- Psychiatry