Journal article
The Maxi-K Channel Opener BMS-204352 Attenuates Regional Cerebral Edema and Neurologic Motor Impairment after Experimental Brain Injury
Journal of cerebral blood flow and metabolism, v 21(4), pp 396-403
Apr 2001
PMID: 11323525
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Abstract
Large-conductance, calcium-activated potassium (maxi-K) channels regulate neurotransmitter release and neuronal excitability, and openers of these channels have been shown to be neuroprotective in models of cerebral ischemia. The authors evaluated the effects of postinjury systemic administration of the maxi-K channel opener, BMS-204352, on behavioral and histologic outcome after lateral fluid percussion (FP) traumatic brain injury (TBI) in the rat. Anesthetized Sprague-Dawley rats (n = 142) were subjected to moderate FP brain injury (n = 88) or surgery without injury (n = 54) and were randomized to receive a bolus of 0.1 mg/kg BMS-204352 (n = 26, injured; n = 18, sham), 0.03 mg/kg BMS-204352 (n = 25, injured; n = 18, sham), or 2% dimethyl sulfoxide (DMSO) in polyethylene glycol (vehicle, n = 27, injured; n = 18, sham) at 10 minutes postinjury. One group of rats was tested for memory retention (Morris water maze) at 42 hours postinjury, then killed for evaluation of regional cerebral edema. A second group of injured/sham rats was assessed for neurologic motor function from 48 hours to 2 weeks postinjury and cortical lesion area. Administration of 0.1 mg/kg BMS-204352 improved neurologic motor function at 1 and 2 weeks postinjury ( P < 0.05) and reduced the extent of cerebral edema in the ipsilateral hippocampus, thalamus, and adjacent cortex ( P < 0.05). Administration of 0.03 mg/kg BMS-204352 significantly reduced cerebral edema in the ipsilateral thalamus ( P < 0.05). No effects on cognitive function or cortical tissue loss were observed with either dose. These results suggest that the novel maxi-K channel opener BMS-204352 may be selectively beneficial in the treatment of experimental TBI.
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Details
- Title
- The Maxi-K Channel Opener BMS-204352 Attenuates Regional Cerebral Edema and Neurologic Motor Impairment after Experimental Brain Injury
- Creators
- Jessica A Cheney - Department of Neurosurgery, University of Pennsylvania, School of Medicine, Philadelphia, PennsylvaniaJustin D Weisser - Department of Neurosurgery, University of Pennsylvania, School of Medicine, Philadelphia, PennsylvaniaFlorence M Bareyre - Department of Neurosurgery, University of Pennsylvania, School of Medicine, Philadelphia, PennsylvaniaHelmut L Laurer - Department of Neurosurgery, University of Pennsylvania, School of Medicine, Philadelphia, PennsylvaniaKathryn E Saatman - Department of Neurosurgery, University of Pennsylvania, School of Medicine, Philadelphia, PennsylvaniaRamesh Raghupathi - Veterans Administration Medical Center, Philadelphia, PennsylvaniaValentin Gribkoff - Neuroscience Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut, U.S.AJohn E Starrett - Neuroscience Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut, U.S.ATracy K McIntosh - Veterans Administration Medical Center, Philadelphia, Pennsylvania
- Publication Details
- Journal of cerebral blood flow and metabolism, v 21(4), pp 396-403
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000168073300008
- Scopus ID
- 2-s2.0-0035049854
- Other Identifier
- 991014877833504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Hematology
- Neurosciences