Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
The MicroRNA miR-155 Is Essential in Fibrosis
Non-coding RNA, v 5(1), p23
01 Mar 2019
PMID: 30871125
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The function of microRNAs (miRNAs) during fibrosis and the downstream regulation of gene expression by these miRNAs have become of great biological interest. miR-155 is consistently upregulated in fibrotic disorders, and its ablation downregulates collagen synthesis. Studies demonstrate the integral role of miR-155 in fibrosis, as it mediates TGF-beta 1 signaling to drive collagen synthesis. In this review, we summarize recent findings on the association between miR-155 and fibrotic disorders. We discuss the cross-signaling between macrophages and fibroblasts that orchestrates the upregulation of collagen synthesis mediated by miR-155. As miR-155 is involved in the activation of the innate and adaptive immune systems, specific targeting of miR-155 in pathologic cells that make excessive collagen could be a viable option before the depletion of miR-155 becomes an attractive antifibrotic approach.
Metrics
Details
- Title
- The MicroRNA miR-155 Is Essential in Fibrosis
- Creators
- Mousa G. Eissa - Drexel UniversityCarol M. Artlett - Drexel University
- Publication Details
- Non-coding RNA, v 5(1), p23
- Publisher
- Mdpi
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000572557400001
- Scopus ID
- 2-s2.0-85063969020
- Other Identifier
- 991019168185704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Genetics & Heredity