Journal article
The Na +-Ca ++ exchanger in central nerve endings: The relationship between its pharmacological blockade and dopamine release from tuberoinfundibular hypothalamic neurons
Neurochemistry international, v 20(MAR), pp 95-99
1992
PMID: 1365465
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
2′,4′-Dimethylbenzamiloride (DMB), an inhibitor of Na
+-Ca
++ antiporter dose-dependently (10–100 μM) inhibited Na
+-dependent
45Ca
++ efflux from brain synaptosomes. This compound was also able to stimulate basal release of [
3H]DA from superfused TIDA neurons. Another amiloride analogue, 5-N-methyl-N-guanidinocarbonylmethylamiloride (MGCMA, 100–300 μM), which lacks of inhibitory properties on the Na
+-Ca
++ antiporter, failed to modify basal [
3H]DA release from TIDA neurons. In addition, when the antiporter operates as a Ca
++-influx pathway, DMB dose-dependently inhibited Na
+-dependent
45Ca
++ uptake in brain synaptosomes, whereas it did not prevent K
+-induced
45Ca
++ uptake, which reflects the activation of voltage-operated Ca
++ channels. Finally DMB inhibited ouabain-induced [
3H]DA release, which depends on the activation of the Na
+-Ca
++ exchanger due to the inhibition of the Na
+/K
+-ATPase pump.
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Details
- Title
- The Na +-Ca ++ exchanger in central nerve endings: The relationship between its pharmacological blockade and dopamine release from tuberoinfundibular hypothalamic neurons
- Creators
- Lucio Annunziato - University of Chieti-PescaraMaurizio Taglialatela - University of Naples Federico IILorella M.T. Canzoniero - University of Naples Federico IIAlessandro Fatatis - University of Naples Federico IIGianfranco Di Rienzo - University of Naples Federico II
- Publication Details
- Neurochemistry international, v 20(MAR), pp 95-99
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:A1992HL80300018
- Scopus ID
- 2-s2.0-0026538288
- Other Identifier
- 991020099211704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences