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Journal article
The Ocular Surface Microbiome in Homeostasis and Dysbiosis
Microorganisms, v 13(9), 1992
27 Aug 2025
PMID: 41011324
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
The ocular surface microbiome consists of microorganisms that play an important role in maintaining homeostasis and preventing disease from invading pathogens. Commensal microbes on the ocular surface interact with cells and molecules of the ocular surface immune system to promote immune tolerance to the normal flora of the ocular surface and facilitate immune protection against invading pathogenic microbes, which allows for a disease-free ocular surface. Various factors can impact the composition, distribution, and diversity of the ocular surface microbiome, including age, gender, disease state, antibiotic treatment, and contact lens use. In addition, there is no cohesive consensus on the species that make up the ocular surface microbes. There is, however, thorough research present on other similar mucosal membranes, such as the gut and oral mucosa, that share similarities with the ocular mucosa. Exploring the relationship of different mucosae allows us to explore treatment options for common ocular diseases such as dry eye syndrome. This review highlights studies that define the ocular surface microbiome, its diversity and composition, host–immune interactions at the ocular surface, factors that cause dysbiosis of the ocular surface microbiome, the impact of dysbiosis on the ocular surface microbiome, and microbiome-based therapy.
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Details
- Title
- The Ocular Surface Microbiome in Homeostasis and Dysbiosis
- Creators
- Fiza Tariq - Drexel University, The Eye Institute (TEI) [Historical]Navpreet Hehar - Drexel University, The Eye Institute (TEI) [Historical]De Gaulle I Chigbu (Corresponding Author) - Drexel University, Pennsylvania College of Optometry (PCO)
- Publication Details
- Microorganisms, v 13(9), 1992
- Publisher
- MDPI
- Number of pages
- 25
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- The Eye Institute (TEI) [Historical]; Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:001580544500001
- Scopus ID
- 2-s2.0-105017406625
- Other Identifier
- 991022083454704721
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- Web of Science research areas
- Microbiology