Journal article
The Osteogenic Peptide P-15 for Bone Regeneration: A Narrative Review of the Evidence for a Mechanism of Action
Bioengineering (Basel), v 11(6), p599
01 Jun 2024
PMID: 38927835
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bone regeneration is a complex multicellular process involving the recruitment and attachment of osteoprogenitors and their subsequent differentiation into osteoblasts that deposit extracellular matrixes. There is a growing demand for synthetic bone graft materials that can be used to augment these processes to enhance the healing of bone defects resulting from trauma, disease or surgery. P-15 is a small synthetic peptide that is identical in sequence to the cell-binding domain of type I collagen and has been extensively demonstrated in vitro and in vivo to enhance the adhesion, differentiation and proliferation of stem cells involved in bone formation. These events can be categorized into three phases: attachment, activation and amplification. This narrative review summarizes the large body of preclinical research on P-15 in terms of these phases to describe the mechanism of action by which P-15 improves bone formation. Knowledge of this mechanism of action will help to inform the use of P-15 in clinical practice as well as the development of methods of delivering P-15 that optimize clinical outcomes.
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Details
- Title
- The Osteogenic Peptide P-15 for Bone Regeneration: A Narrative Review of the Evidence for a Mechanism of Action
- Creators
- Cooper T. Cheng - Allegheny General HospitalPraveer S. Vyas - Allegheny General HospitalEdward James McClain - Allegheny Health NetworkThomay-Claire Ayala Hoelen - Maastricht UniversityJacobus Johannes Chris Arts - Maastricht UniversityColin McLaughlin - Allegheny Gen Hosp, Neurosci Inst, Allegheny Hlth Network, Pittsburgh, PA 15212 USADaniel T. Altman - Allegheny General HospitalAlexander K. Yu - Allegheny General HospitalBoyle C. Cheng - Allegheny General Hospital
- Publication Details
- Bioengineering (Basel), v 11(6), p599
- Publisher
- Mdpi
- Number of pages
- 18
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Orthopedic/Orthopaedic Surgery; Surgery; Neurosurgery
- Web of Science ID
- WOS:001254724500001
- Scopus ID
- 2-s2.0-85197859728
- Other Identifier
- 991021897303304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Engineering, Biomedical