Journal article
The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens
International journal of obesity (2005)
05 Feb 2026
PMID: 41644794
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Physiology Of the WEight Reduced State (POWERS) study is a multi-center clinical trial designed to understand the physiological basis for observed variability in weight regain following intentional weight loss among US adults. The primary dependent variable is weight regain over one year following a 7% or greater supervised weight loss. The overarching design and study organization, along with rationale and history of the POWERS study and outcomes measures are described in accompanying papers. This paper provides the rationale for and description of biospecimens samples that will ultimately inform on the molecular and cellular basis of the physiological variability that contributes to the regulation of energy balance in the weight reduced state. Participants will be 205 healthy adults (n = 205), aged 25-59 years, with body mass index (BMI) 30- ≤ 40 kg/m
. Biospecimens will be collected prior to weight loss (baseline, BL), immediately following weight loss via lifestyle intervention (T0), and then four (T4) and twelve (T12) months after weight loss. Blood will be collected in the fasting state and following a meal challenge designed to induce hormones related to satiety. Weight change from T0 to T12 will be the primary outcome variable. Biospecimens to be collected include plasma, serum, peripheral blood mononuclear cells (PBMCs), DNA, urine, feces, adipose and skeletal muscle tissue. All samples will be biobanked at each site. This manuscript describes the rationale for the biospecimens chosen to assess contributors to homeostatic mechanisms that drive observed variability of weight regain after weight loss.
Metrics
1 Record Views
Details
- Title
- The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens
- Creators
- Michael Rosenbaum - Columbia University Irving Medical CenterKelly C Allison - University of PennsylvaniaMaren R Laughlin - National Institute of Diabetes and Digestive and Kidney DiseasesStephanie S Kelley - University of PittsburghJoel Nunez-Matos - Columbia University Irving Medical CenterMichael Rickles - University of PennsylvaniaLillian Chau - University of PennsylvaniaGary Wu - University of PennsylvaniaPayman Zamani - University of PennsylvaniaKathryn J Whyte - Columbia University Irving Medical CenterRudolph L Leibel - Columbia University Irving Medical CenterMatthew R Hayes - University of PennsylvaniaPOWERS Consortium
- Publication Details
- International journal of obesity (2005)
- Grant note
- T32 DK007559 / NIDDK NIH HHS P30 DK026687 / NIDDK NIH HHS K26 DK138418 / NIDDK NIH HHS UH3 DK128302 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001686792600001
- Scopus ID
- 2-s2.0-105030854227
- Other Identifier
- 991022197020304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics