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Journal article
The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition
American journal of Alzheimer's disease and other dementias, v 29(4), pp 303-310
Jun 2014
PMID: 24421411
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Loss of synaptic function is critical in the pathogenesis of Alzheimer's disease (AD) and other central nervous system (CNS) degenerations. A promising candidate in the regulation of synaptic function is Shank, a protein that serves as a scaffold for excitatory synaptic receptors and proteins. Loss of Shank alters structure and function of the postsynaptic density (PSD). Shank proteins are associated with N-methyl-d-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor loss at the PSD in AD; mutations in Shank also lead to autism spectrum disorders (ASDs) and schizophrenia, both of which affect cognition, suggesting that Shank may play a common pathologic role in AD, ASD, and schizophrenia. Shank protein directly associates with insulin receptor substrate protein p53 in PSD. Insulin and insulin sensitizers have been used in clinical trials for these diseases; this suggests that insulin signals may alter protein homeostasis at the shank-postsynaptic platform in PSDs; insulin could improve the function of synapses in these diseases.
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Details
- Title
- The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition
- Creators
- Frances Chow - Drexel UniversityYuesong Gong - Drexel UniversityCarol F Lippa - Drexel University
- Publication Details
- American journal of Alzheimer's disease and other dementias, v 29(4), pp 303-310
- Publisher
- Sage
- Grant note
- 1-R21AG031388 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000340200800003
- Scopus ID
- 2-s2.0-84906672292
- Other Identifier
- 991019312374604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Geriatrics & Gerontology