Journal article
The Prognostic Importance of Frailty in Cancer Survivors
Journal of the American Geriatrics Society (JAGS), v 63(12), pp 2538-2543
01 Dec 2015
PMID: 26566767
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ObjectivesTo quantify the prognostic importance of prefrailty and frailty in a population-based sample of cancer survivors.
DesignThe Third National Health and Nutrition Examination Survey mortality-linked prospective cohort study.
SettingEighty-nine survey locations across the United States.
ParticipantsPopulation-based sample of older adults (average age 72.2) with a self-reported diagnosis of non-skin-related cancer (N = 416).
MeasurementsThe primary outcome was all-cause mortality. Frailty components included low weight for height, slow walking, weakness, exhaustion, and low physical activity. Participants with none of the five criteria were classified as nonfrail, those with one or two as prefrail, and those with three or more as frail.
ResultsThe prevalence of prefrailty was 37.3% and of frailty was 9.1%. During a median follow-up of 11.2 years, 319 (76.7%) participants died. Median survival was 13.9 years for participants classified as nonfrail, 9.5 years for those classified as prefrail, and 2.5 years for those classified as frail. Cancer survivors classified as prefrail (hazard ratio (HR) = 1.84, 95% confidence interval (CI) = 1.28-2.65, P = .001) or frail (HR = 2.79, 95% CI = 1.34-5.81, P = .006) had a higher risk of premature mortality than those classified as nonfrail.
ConclusionPrefrailty and frailty are prevalent clinical syndromes that may confer greater risk of premature mortality in older adult cancer survivors. Identifying frail cancer survivors and targeting interventions for them may be a strategy to improve survival after cancer.
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Details
- Title
- The Prognostic Importance of Frailty in Cancer Survivors
- Creators
- Justin C. Brown - University of PennsylvaniaMichael O. Harhay - University of PennsylvaniaMeera N. Harhay - Drexel University
- Publication Details
- Journal of the American Geriatrics Society (JAGS), v 63(12), pp 2538-2543
- Publisher
- Wiley
- Number of pages
- 6
- Grant note
- K23DK105207 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) F31-CA192560; R21-CA182726 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) K23-DK105207 / National Institute of Diabetes and Digestive and Kidney Diseases of National Institutes of Health F31CA192560 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) F31HL127947 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) F31-HL127947 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000367193300015
- Scopus ID
- 2-s2.0-84951275076
- Other Identifier
- 991019335233904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Gerontology