Journal article
The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication
Genes, v 4(1), pp 1-32
Mar 2013
PMID: 23599899
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Eukaryotic cells must accurately and efficiently duplicate their genomes during each round of the cell cycle. Multiple linear chromosomes, an abundance of regulatory elements, and chromosome packaging are all challenges that the eukaryotic DNA replication machinery must successfully overcome. The replication machinery, the “replisome” complex, is composed of many specialized proteins with functions in supporting replication by DNA polymerases. Efficient replisome progression relies on tight coordination between the various factors of the replisome. Further, replisome progression must occur on less than ideal templates at various genomic loci. Here, we describe the functions of the major replisome components, as well as some of the obstacles to efficient DNA replication that the replisome confronts. Together, this review summarizes current understanding of the vastly complicated task of replicating eukaryotic DNA.
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Details
- Title
- The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication
- Creators
- Adam R Leman - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USAEishi Noguchi - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
- Publication Details
- Genes, v 4(1), pp 1-32
- Publisher
- MDPI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000209242700001
- Scopus ID
- 2-s2.0-84875164760
- Other Identifier
- 991014878043104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity