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Journal article
The Rich Get Richer: Brain Injury Elicits Hyperconnectivity in Core Subnetworks
PloS one, v 9(8), pp e104021-e104021
14 Aug 2014
PMID: 25121760
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There remains much unknown about how large-scale neural networks accommodate neurological disruption, such as moderate and severe traumatic brain injury (TBI). A primary goal in this study was to examine the alterations in network topology occurring during the first year of recovery following TBI. To do so we examined 21 individuals with moderate and severe TBI at 3 and 6 months after resolution of posttraumatic amnesia and 15 age- and education-matched healthy adults using functional MRI and graph theoretical analyses. There were two central hypotheses in this study: 1) physical disruption results in increased functional connectivity, or hyperconnectivity, and 2) hyperconnectivity occurs in regions typically observed to be the most highly connected cortical hubs, or the "rich club". The current findings generally support the hyperconnectivity hypothesis showing that during the first year of recovery after TBI, neural networks show increased connectivity, and this change is disproportionately represented in brain regions belonging to the brain's core subnetworks. The selective increases in connectivity observed here are consistent with the preferential attachment model underlying scale-free network development. This study is the largest of its kind and provides the unique opportunity to examine how neural systems adapt to significant neurological disruption during the first year after injury.
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Details
- Title
- The Rich Get Richer: Brain Injury Elicits Hyperconnectivity in Core Subnetworks
- Creators
- Frank G. Hillary - Pennsylvania State UniversitySarah M. Rajtmajer - Pennsylvania State UniversityCristina A. Roman - Pennsylvania State UniversityJohn D. Medaglia - Pennsylvania State UniversityJulia E. Slocomb-Dluzen - Penn State Milton S. Hershey Medical CenterVincent D. Calhoun - Mind Research NetworkDavid C. Good - Penn State Milton S. Hershey Medical CenterGlenn R. Wylie - Kessler Foundation
- Publication Details
- PloS one, v 9(8), pp e104021-e104021
- Publisher
- Public Library Science
- Number of pages
- 15
- Grant note
- Social Sciences Research Institute at Pennsylvania State University in University Park, Pennsylvania 09.001.BIR1 / New Jersey Commission for Brain Injury Research
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000341017000024
- Scopus ID
- 2-s2.0-84905970674
- Other Identifier
- 991019296563204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences