Journal article
The Road Well Traveled: From Inflammasomes to Collagen Export During Fibrosis
Sclerosis, v 2(4), pp 378-393
05 Dec 2024
Abstract
Collagen export from the endoplasmic reticulum is required for normal tissue homeostasis, and yet, in fibrotic disorders, this process is significantly upregulated. In this review, we will focus on the signaling cascade from the inflammasome and how that promotes collagen via proinflammatory/profibrotic cytokines. Concordantly, these cytokines also induce the expression of TANGO1 to cope with the increased movement of collagen through the endoplasmic reticulum. In normal and fibrotic cells, this pathway is finely tuned to meet the necessary demand in collagen export. Currently, the role of TANGO1 in fibrotic disorders and how the inflammasome induces its expression is not well understood. In this review, we will assimilate the current information concerning inflammasome activation and how it induces TANGO1 expression, leading to fibrosis.
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Details
- Title
- The Road Well Traveled: From Inflammasomes to Collagen Export During Fibrosis
- Creators
- Carol M. Artlett - Drexel University
- Publication Details
- Sclerosis, v 2(4), pp 378-393
- Publisher
- MDPI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Other Identifier
- 991022016400604721