Journal article
The Role of Non-Statin Lipid Lowering Therapies to Reduce ASCVD Events in Primary Prevention
Current atherosclerosis reports, v 27(1), p46
02 Apr 2025
PMID: 40172616
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Atherosclerotic cardiovascular disease (ASCVD) remains a leading global health challenge, with low-density lipoprotein (LDL) cholesterol a pivotal risk factor. While statins are cornerstone therapy for lowering LDL cholesterol, many high-risk primary prevention patients are unable to tolerate statin therapy and do not achieve their guideline directed LDL cholesterol goal. For these patients, non-statin therapies offer complementary and alternative approaches to LDL cholesterol reduction.
Recent advancements in non-statin therapies have expanded the options available to clinicians to lower LDL cholesterol in high-risk primary prevention patients. Yet these medications are often under-utilized in clinical practice. Observational studies, Mendelian randomization studies, and randomized clinical trials support the role of non-statin LDL cholesterol lowering therapies in the primary prevention of ASCVD. This review summarizes the evidence supporting their use for the primary prevention of ASCVD and offers practical suggestions as to how clinicians can integrate these medications into their clinical practice.
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Details
- Title
- The Role of Non-Statin Lipid Lowering Therapies to Reduce ASCVD Events in Primary Prevention
- Creators
- Chukwuemezie Kamanu - Thomas Jefferson University HospitalDean G Karalis - Thomas Jefferson University Hospital
- Publication Details
- Current atherosclerosis reports, v 27(1), p46
- Publisher
- CURRENT MEDICINE GROUP; PHILADELPHIA
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001458225500002
- Scopus ID
- 2-s2.0-105002035640
- Other Identifier
- 991022043943404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Peripheral Vascular Disease