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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The Role of Oxidative Stress in Aseptic Loosening of Total Hip Arthroplasties
The Journal of arthroplasty, v 29(4), pp 843-849
Apr 2014
PMID: 24290740
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study investigated the hypothesis that wear particle-induced oxidative stress initiates osteolysis after total hip arthroplasty (THA). Patient radiographs were scored for osteolysis and periprosthetic tissues were immunostained and imaged to quantify polyethylene wear, inflammation, and five osteoinflammatory and oxidative stress-responsive factors. These included high mobility group protein-B1 (HMGB1), cyclooxygenase-2 (COX2), inducible nitric oxide synthase (iNOS), 4-hydroxynonenal (4-HNE), and nitrotyrosine (NT). The results show wear debris correlated with inflammation, 4-HNE, NT and HMGB1, whereas inflammation only correlated with NT and HMGB1. Similar to wear debris and inflammation, osteolysis correlated with HMGB1. Additionally, osteolysis correlated with COX2 and 4-HNE, but not iNOS or NT. Understanding the involvement of oxidative stress in wear-induced osteolysis will help identify diagnostic biomarkers and therapeutic targets to prevent osteolysis after THA.
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Details
- Title
- The Role of Oxidative Stress in Aseptic Loosening of Total Hip Arthroplasties
- Creators
- Marla J. Steinbeck - Drexel UniversityLauren J. Jablonowski - Drexel UniversityJavad Parvizi - Rothman InstituteTheresa A. Freeman - Thomas Jefferson UniversityC S Pitchumoni
- Publication Details
- The Journal of arthroplasty, v 29(4), pp 843-849
- Publisher
- Elsevier
- Grant note
- NIH R01 AR47904 / NIAMS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000334094000043
- Scopus ID
- 2-s2.0-84896544135
- Other Identifier
- 991019357764404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics