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Journal article
The Role of Previous History of Muscle Wasting in Burn Outcomes—A Burn Care Quality Platform Study
European burn journal, v 6(4), 61
02 Dec 2025
PMID: 41440045
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Background: Burn patients can suffer prolonged hospital stays, infections, and wound breakdown. Given the complexity of burns, it is often difficult to determine which underlying factors contribute to complications. The Burn Care Quality Platform (BCQP) is the largest database of burn patients globally available, and it accounts for underlying or coinciding disease conditions present in burn patients. Muscle wasting conditions, such as sarcopenia, cachexia, and protein malnutrition, are suspected of causing worse outcomes. Prior analysis of BCQP data (2000–2017) demonstrated that patients with muscle wasting had prolonged hospitalization and adverse outcomes. Methods: Building on our previous work, we extended logistic regression analysis to BCPQ data through 2022 to assess whether reporting and outcomes had changed. Results: Updated BCQP data demonstrated a statistically significant increase in mortality in cachexia vs. non-muscle wasting patients (Odds Ratio [OR]: 2.2 [95% Confidence Interval (CI): 1.3–3.7], p = 0.004), but no increase in mortality was seen with protein malnutrition (OR: 1.1 [95% CI: 0.93–1.35], p = 0.239). However, the diagnosis rate of muscle wasting conditions decreased by 53% since the previous analysis, suggesting a potential under-reporting of these diagnoses in BCQP patients. Conclusions: Burn care could be augmented by better diagnosis of underlying conditions that predispose to muscle wasting.
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Details
- Title
- The Role of Previous History of Muscle Wasting in Burn Outcomes—A Burn Care Quality Platform Study
- Creators
- Elizabeth Blears - Allegheny Health NetworkJagger Godarzi (Corresponding Author) - Drexel University, Pharmacology and PhysiologySharon Shania - Drexel University, College of MedicineKrish Kondisetti - Philadelphia College of Osteopathic MedicineJulie Caffrey - Johns Hopkins UniversityAndrew J. Murton - The University of Texas Medical Branch at Galveston
- Publication Details
- European burn journal, v 6(4), 61
- Publisher
- MDPI
- Number of pages
- 21
- Grant note
- Reading Hospital Foundation awarded to the Department of Plastic and Reconstructive Surgery at Reading Hospital-Tower Health
This work was supported by a gift from the Reading Hospital Foundation awarded to the Department of Plastic and Reconstructive Surgery at Reading Hospital-Tower Health in March 2025.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology
- Web of Science ID
- WOS:001646350300001
- Scopus ID
- 2-s2.0-105025749045
- Other Identifier
- 991022138982904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Critical Care Medicine
- Dermatology