Journal article
The Role of the NLRP3 Inflammasome in Fibrosis
The open rheumatology journal, v 6(1), pp 80-86
2012
PMID: 22802905
Abstract
Fibrosis leads to the deposition of collagens in organs and tissues. The resulting pathology induces a loss of function in the organ it is manifested in and this loss of function modulates the morbidity and mortality in that individual. Indeed, approximately 45% of all deaths in the Western world can be attributed to fibrosis and there are no FDA approved drugs for the treatment of fibrosis. The recent discovery of the inflammasome has led to a plethora of studies investigating this inflammatory signaling pathway in a wide variety of pathogen associated diseases. Many studies have focused on the NLRP3 inflammasome and this inflammasome is activated by a wide variety of cellular alarm signals. Once activated, caspase-1 is cleaved, inducing the secretion of IL-1β and IL-18 that signal to aid in the clearance of invading organisms. However, as the knowledge of the inflammasome has expanded, it was found that it can directly control collagen synthesis, leading to the increased deposition of collagens in the tissues such as the lung, liver, heart, and skin. Mice lacking the inflammasome adaptor protein, ASC, failed to become fibrotic when exposed to bleomycin. Inhibition of caspase-1 activity in fibroblasts from patients with the fibrotic disease systemic sclerosis, decreased collagen synthesis and reduced α-smooth muscle actin expression in myofibroblasts. Taken together, these observations suggest that the inflammasome can drive the fibrotic response and paves the way for novel therapeutics to be identified.
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103 citations in Scopus
Details
- Title
- The Role of the NLRP3 Inflammasome in Fibrosis
- Creators
- Carol M Artlett - Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia PA 19129, USA
- Publication Details
- The open rheumatology journal, v 6(1), pp 80-86
- Series
- Suppl 1
- Publisher
- Bentham Open
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Scopus ID
- 2-s2.0-84863906876
- Other Identifier
- 991014878151904721