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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The SOMATICS collaborative: Introduction to a National Institute on Drug Abuse cooperative study of pharmacotherapy for opioid treatment in criminal justice settings
Contemporary clinical trials, v 48
01 May 2016
PMID: 27180088
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Among the nearly 750,000 inmates in U.S. jails, 12% report using opioids regularly, 8% report use in the month prior to their offense, and 4% report use at the time of their offense. Although ample evidence exists that medications effectively treat Opiate Use Disorder (OUD) in the community, strong evidence is lacking in jail settings. The general lack of medications for OUD in jail settings may place persons suffering from OUD at high risk for relapse to drug use and overdose following release from jail.
Methods: The three study sites in this collaborative are pooling data for secondary analyses from three open-label randomized effectiveness trials comparing: (1) the initiation of extended-release naltrexone [XR-NTX] in Sites 1 and 2 and interim methadone in Site 3 with enhanced treatment-as usual (ETAU); (2) the additional benefit of patient navigation plus medications at Sites 2 and 3 vs. medication alone vs. ETAU. Participants are adults with OUD incarcerated in jail and transitioning to the community.
Results: We describe the rationale, specific aims, and designs of three separate studies harmonized to enhance their scientific yield to investigate how to best prevent jail inmates from relapsing to opioid use and associated problems as they transition back to the community.
Conclusions: Conducting drug abuse research during incarceration is challenging and study designs with data harmonization across different sites can increase the potential value of research to develop effective treatments for individuals in jail with OUD. Published by Elsevier Inc.
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Details
- Title
- The SOMATICS collaborative: Introduction to a National Institute on Drug Abuse cooperative study of pharmacotherapy for opioid treatment in criminal justice settings
- Creators
- Redonna K. Chandler - National Institute on Drug AbuseMatthew S. Finger - National Institute on Drug AbuseDavid Farabee - Neurobehavioral SystemsRobert P. Schwartz - Friends Research InstituteTimothy Condon - University of New MexicoLaura J. Dunlap - RTI InternationalGary A. Zarkin - RTI InternationalKathryn McCollister - University of MiamiRyan D. McDonald - College Station Medical CenterEugene Laska - New York UniversityDavid Bennett - Neurobehavioral SystemsSharon M. Kelly - Friends Research InstituteMaureen Hillhouse - Neurobehavioral SystemsShannon G. Mitchell - Friends Research InstituteKevin E. O'Grady - University of Maryland, College ParkJoshua D. Lee - College Station Medical Center
- Publication Details
- Contemporary clinical trials, v 48
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- U01 DA033336; U01 DA034743; U01 DA013636 / National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000378458900022
- Scopus ID
- 2-s2.0-84968912313
- Other Identifier
- 991020785755604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy