Journal article
The Sickle-Cell Fiber Revisited
Biomolecules (Basel, Switzerland), v 13(3), p413
22 Feb 2023
PMID: 36979347
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sickle cell disease is the consequence of a single point mutation on the surface of the β chains of the hemoglobin molecule leading to the formation of rigid polymers that disrupt circulation. It has long been established that the polymers are comprised of seven pairs of double strands that are twisted replicas of the double strands found in crystals. Here, we review several newer developments that elaborate on that simple model and provide deeper insights into the process.
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Details
- Title
- The Sickle-Cell Fiber Revisited
- Creators
- Marilyn F Bishop - Virginia Commonwealth UniversityFrank A Ferrone - Drexel University
- Publication Details
- Biomolecules (Basel, Switzerland), v 13(3), p413
- Publisher
- MDPI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000954161600001
- Scopus ID
- 2-s2.0-85151112800
- Other Identifier
- 991020346955004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology