Journal article
The Society of Thoracic Surgeons Intermacs 2024 Annual Report: Focus on Outcomes in Younger Patients
The Annals of thoracic surgery, v 119(1)
21 Oct 2024
PMID: 39442906
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The 15th Annual Report from The Society of Thoracic Surgeons (STS) Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs) includes 29,634 continuous-flow left ventricular assist devices (LVAD) from the 10-year period between 2014 through 2024. The outcomes reported here demonstrate continued improved survival in the current era of fully magnetically levitated (Mag-Lev) devices, with a significantly higher 1-year (85.7% versus 78.4%) and 5-year (59.7% versus 43.7%) survival than those receiving non-Mag-Lev devices. Mag-Lev recipients are experiencing a lower incidence of adverse events, including freedom from GI bleeding (72.6%), device malfunction (82.9%) and stroke (86.7%) at 5 years. Additionally, a focus on a subgroup of patients less than 50 years of age have demonstrated superior outcomes in both survival (91.6% survival at 1 year and 72.6% survival at 5 years) and decreased incidence of adverse events compared to older recipients. This younger cohort also demonstrated more tolerance to the characteristics of sex, race, ethnicity and psychosocial indicators that are associated with worse outcomes following heart transplantation (HT). Based upon these data, a potential net prolongation of life may be realized by considering prolonged LVAD support prior to HT in this population. These analyses provide preliminary data that could positively influence adoption of LVAD technology in groups previously not seen as candidates for this therapy, while providing a more responsible donor allocation strategy for advanced heart failure patients.
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Details
- Title
- The Society of Thoracic Surgeons Intermacs 2024 Annual Report: Focus on Outcomes in Younger Patients
- Creators
- Dan M. Meyer - Baylor University Medical CenterAditi Nayak - Baylor Scott & White HealthKatherine L. Wood - University of Rochester Medical CenterVanessa Blumer - Alaska Heart and Vascular InstituteSarah Schettle - Mayo Clinic in ArizonaChris Salerno - University of ChicagoDevin Koehl - Kirklin ClinicRyan Cantor - Kirklin ClinicJames K. Kirklin - Kirklin ClinicJeffrey P. Jacobs - Florida CollegeThomas Cascino - University of Michigan–Ann ArborFrancis D. Pagani - University of Michigan–Ann ArborManreet K. Kanwar - Allegheny Health Network
- Publication Details
- The Annals of thoracic surgery, v 119(1)
- Publisher
- Elsevier; NEW YORK
- Number of pages
- 25
- Grant note
- Society of Thoracic Surgeons (STS)University of Alabama at Birmingham (UAB) healthcare technology start-up companyCarmatBlue Cross/Blue Shield of Michigan as Associate Director of the Michigan Society of Thoracic and Cardiovascular Sur-geons Quality Collaborative
K. Kirklin discloses receiving partial salary support from the Society of Thoracic Surgeons (STS) as Director of the Data Center for STS Inter-macs and being part owner and President of Kirkl in Solutions, Inc., a University of Alabama at Birmingham (UAB) healthcare technology start-up company. Francis D. Pagani is a noncompensated ad-hoc scientific advisor for Abbott, Berlin Heals, FineHeart, and Medtronic, a non-compensated medical monitor for Abiomed, Scientific advisor for BrioHealth with travel compensation; and a member of the Data and Safety Monitoring Board (DSMB) for Carmat; and receives partial salary support from Blue Cross/Blue Shield of Michigan as Associate Director of the Michigan Society of Thoracic and Cardiovascular Sur-geons Quality Collaborative. Manreet K. Kanwar is on the Advisory Board for Abiomed, Abbott and CorWave, on CEC for BiVACOR, and a speaker for Abiomed. The other authors have no conflicts of interest to disclose.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiology
- Web of Science ID
- WOS:001391075400001
- Scopus ID
- 2-s2.0-85210068779
- Other Identifier
- 991021944100704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery