Journal article
The Use of Breast-specific Gamma Imaging as a Low-Cost Problem-Solving Strategy for Avoiding Biopsies in Patients With Inconclusive Imaging Findings on Mammography and Ultrasonography
Journal of breast imaging, v 6(5), pp 502-512
11 Sep 2024
PMID: 39162574
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective
To evaluate the clinical performance and financial costs of breast-specific gamma imaging (BSGI) as a biopsy-reducing problem-solving strategy in patients with inconclusive diagnostic imaging findings.
Methods
A retrospective analysis of all patients for whom BSGI was utilized for inconclusive imaging findings following complete diagnostic mammographic and sonographic evaluation between January 2013 and December 2018 was performed. Positive BSGI findings were correlated and biopsied with either US or stereotactic technique with confirmation by clip location and pathology. After a negative BSGI result, patients were followed for a minimum of 24 months or considered lost to follow-up and excluded (22 patients). Results of further imaging studies, biopsies, and pathology results were analyzed. Net savings of avoided biopsies were calculated based on average Medicare charges.
Results
Four hundred and forty female patients from 30 to 95 years (mean 55 years) of age were included in our study. BSGI demonstrated a negative predictive value (NPV) of 98.4% (314/319) and a positive predictive value for biopsy of 35.5% (43/121). The overall sensitivity was 89.6% (43/48), and the specificity was 80.1% (314/392). In total, 78 false positive but only 5 false negative BSGI findings were identified. Six hundred and twenty-one inconclusive imaging findings were analyzed with BSGI and a total of 309 biopsies were avoided. Estimated net financial savings from avoided biopsies were $646 897.
Conclusion
In the management of patients with inconclusive imaging findings on mammography or ultrasonography, BSGI is a problem-solving imaging modality with high NPV that helps avoid costs of image-guided biopsies.
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Details
- Title
- The Use of Breast-specific Gamma Imaging as a Low-Cost Problem-Solving Strategy for Avoiding Biopsies in Patients With Inconclusive Imaging Findings on Mammography and Ultrasonography
- Creators
- Andrew Ko - Riverside Regional Medical CenterAlexander M. Vo - Santa Clara Valley Medical CenterNathaniel Miller - Riverside Regional Medical CenterAnnie Liang - Brown UniversityMaia Baumbach - Georgia Institute of TechnologyJay Riley Argue - University of WashingtonNathaniel Manche - Medical University of South CarolinaLuis Gonzalez - University of FloridaNicholas Austin - Cleveland ClinicPhilip Carver - Riverside Regional Medical CenterJoseph Procell - Riverside Regional Medical CenterHassan Elzein - Virginia Commonwealth UniversityMargaret Pan - Brigham and Women's HospitalNadine Zeidan - Riverside Regional Medical CenterWilliam Kasper - Riverside Regional Medical CenterSamuel Speer - Oregon Health & Science UniversityYizhi Liang - Radiology AssociatesBenjamin J. Pettus - Radiology Associates
- Publication Details
- Journal of breast imaging, v 6(5), pp 502-512
- Publisher
- Oxford University Press
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:001293807400001
- Scopus ID
- 2-s2.0-85203960390
- Other Identifier
- 991022202097004721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging