Journal article
The Use of an Autologous Cell Harvesting and Processing Device to Decrease Surgical Procedures and Expedite Healing in Two Pediatric Burn Patients
Wounds (King of Prussia, Pa.), v 31(12), pp 316-321
01 Dec 2019
PMID: 31833837
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Autologous cell harvesting and processing devices are designed to facilitate the harvesting of cells using enzymatic and physical disruption techniques to immediately apply non-cultured autologous cell suspension (ACS) to the wound area. Objective: This case report evaluates clinical outcomes following application of cellular suspension with split-thickness skin grafts (STSGs) as an adjunct for definitive closure of burn injuries and donor sites in 2 pediatric patients. Material and Methods: The cases were performed under a humanitarian use protocol following institutional review board approval at St. Christopher's Hospital for Children (Philadelphia, PA). Results: The first patient was a 4-year-old girl with partial- and full-thickness (32% total body surface area) burn injuries of her head, trunk, flank, arms, thighs, and feet. The patient was discharged 19 days following ACS treatment. The second patient was an 18-month-old girl with partial- and full-thickness (21% total body surface area) burns involving the bilateral lower extremities. She was discharged 22 days after ACS treatment with widely meshed autograft. Neither patient required additional surgical interventions. All treatment and donor areas for both patients remained uninfected and neither patient experienced any unexpected treatment-related adverse events. Conclusions: These cases are the first of their kind reported in the pediatric population and suggest ACS in conjunction with STSGs can help decrease surgical procedures and expedite healing in pediatric patients with large surface burns.
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Details
- Title
- The Use of an Autologous Cell Harvesting and Processing Device to Decrease Surgical Procedures and Expedite Healing in Two Pediatric Burn Patients
- Creators
- Autumn D. Nanassy - St Christophers Hosp Children, Philadelphia, PA 19134 USAPaul M. Glat - St Christophers Hosp Children, Philadelphia, PA 19134 USABrooke A. Burkey - St Christophers Hosp Children, Philadelphia, PA 19134 USAAmit C. Misra - St Christophers Hosp Children, Philadelphia, PA 19134 USALoreen K. Meyer - St Christophers Hosp Children, Philadelphia, PA 19134 USALisa Gates - St Christophers Hosp Children, Philadelphia, PA 19134 USAWellington J. Davis - St Christophers Hosp Children, Philadelphia, PA 19134 USA
- Publication Details
- Wounds (King of Prussia, Pa.), v 31(12), pp 316-321
- Publisher
- H M P Communications
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Accelerated Career Entry Bachelor of Science in Nursing (BSN); Pediatrics
- Web of Science ID
- WOS:000519743400004
- Scopus ID
- 2-s2.0-85076486153
- Other Identifier
- 991021463679104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Dermatology
- Surgery