Journal article
The Winding Road to Relapse: Forging a New Understanding of Cue-Induced Reinstatement Models and Their Associated Neural Mechanisms
Frontiers in behavioral neuroscience, v 12, pp 17-17
09 Feb 2018
PMID: 29479311
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In drug addiction, cues previously associated with drug use can produce craving and frequently trigger the resumption of drug taking in individuals vulnerable to relapse. Environmental stimuli associated with drugs or natural reinforcers can become reliably conditioned to increase behavior that was previously reinforced. In preclinical models of addiction, these cues enhance both drug self-administration and reinstatement of drug seeking. In this review, we will dissociate the roles of conditioned stimuli as reinforcers from their modulatory or discriminative functions in producing drug-seeking behavior. As well, we will examine possible differences in neurobiological encoding underlying these functional differences. Specifically, we will discuss how models of drug addiction and relapse should more systematically evaluate these different types of stimuli to better understand the neurobiology underlying craving and relapse. In this way, behavioral and pharmacotherapeutic interventions may be better tailored to promote drug use cessation outcomes and long-term abstinence.
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Details
- Title
- The Winding Road to Relapse: Forging a New Understanding of Cue-Induced Reinstatement Models and Their Associated Neural Mechanisms
- Creators
- Mark D. Namba - Arizona State UniversitySeven E. Tomek - Arizona State UniversityM. Foster Olive - Arizona State UniversityJoshua S. Beckmann - University of KentuckyCassandra D. Gipson - Arizona State University
- Publication Details
- Frontiers in behavioral neuroscience, v 12, pp 17-17
- Publisher
- Frontiers Media Sa
- Number of pages
- 22
- Grant note
- R00 DA033373 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K99DA036569 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission R01AA025590 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) R00 DA036569; DA036569-S1; AA AA025590; DA043172 / Public Health Service; United States Department of Health & Human Services; United States Public Health Service
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000424670100001
- Scopus ID
- 2-s2.0-85043454569
- Other Identifier
- 991021955156204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences