Journal article
The Wld S gene modestly prolongs survival in the SOD1 G93A fALS mouse
Neurobiology of disease, v 19(1), pp 293-300
2005
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The “slow Wallerian degeneration” (
Wld
S
) gene is neuroprotective in numerous models of axonal degeneration. Axonal degeneration is an early feature of disease progression in the SOD1
G93A mouse, a widely used model of familial amyotrophic lateral sclerosis (fALS). We crossed the
Wld
S
mouse with the SOD1
G93A mouse to investigate whether the
Wld
S
gene could prolong survival and modify neuropathology in these mice. SOD/
Wld
S
mice showed levels of motor axon loss similar to that seen in SOD1
G93A mice. The presence of the
Wld
S
gene, however, modestly prolonged survival and delayed denervation at the neuromuscular junction. Prolonged survival was more prominent in female mice and did not depend on whether animals were heterozygous or homozygous for the
Wld
S
gene. We also report that SOD1
G93A mice show significant degeneration of sensory axons during the course of disease, supporting previous data from humans demonstrating that ALS is not purely a motor disorder.
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Details
- Title
- The Wld S gene modestly prolongs survival in the SOD1 G93A fALS mouse
- Creators
- Lindsey R. Fischer - Emory UniversityDeborah G. Culver - Emory UniversityAlbert A. Davis - Emory UniversityPhilip Tennant - Emory UniversityMinsheng Wang - Emory UniversityMichael Coleman - Babraham InstituteSeneshaw Asress - Emory UniversityRobert Adalbert - Babraham InstituteGuillermo M. Alexander - Drexel UniversityJonathan D. Glass - Emory University
- Publication Details
- Neurobiology of disease, v 19(1), pp 293-300
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000228672900031
- Scopus ID
- 2-s2.0-20244390181
- Other Identifier
- 991019168561404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences