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The application of 23Na double-quantum-filter (DQF) NMR spectroscopy for the study of spinal disc degeneration
Journal article   Open access   Peer reviewed

The application of 23Na double-quantum-filter (DQF) NMR spectroscopy for the study of spinal disc degeneration

Kristopher J Ooms, Marco Cannella, Alexander J Vega, Michele Marcolongo and Tatyana Polenova
Magnetic resonance in medicine, v 60(2), pp 246-252
Aug 2008
DOI: https://doi.org/10.1002/mrm.21637
PMID: 18666105
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1002/mrm.21637View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Sodium Isotopes - analysis Body Water - chemistry Magnetic Resonance Spectroscopy - methods Humans Intervertebral Disc Displacement - diagnosis Adolescent Diagnosis, Computer-Assisted - methods Intervertebral Disc Displacement - metabolism Water - analysis Signal Processing, Computer-Assisted Aged Sodium Isotopes - chemistry
Degenerative disc disease is an irreversible process that leads to a loss of mechanical integrity and back pain in millions of people. In this report, (23)Na double-quantum-filtered (DQF) NMR spectroscopy is used to study disc tissues in two stages of degeneration. Initial results indicate that the (23)Na DQF signal may be useful for determining the degree of degeneration. The spectral analysis reveals the presence of sodium environments with different residual quadrupolar couplings and T(2) relaxation times that we attribute to different regions, or compartments, corresponding to different biochemical regions in the tissue. In general it is found that there are compartments with no residual quadrupolar couplings, compartments with moderate couplings (200 to 1000 Hz), and compartments with couplings ranging from 1500 to 3000 Hz. The results indicate that (23)Na DQF NMR spectroscopy provides a probe of the degenerative state of the intervertebral disc tissues, and might hold potential as a novel diagnostic method for detection of disc degeneration.

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14 citations in Web of Science
17 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Radiology, Nuclear Medicine & Medical Imaging
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