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The association of liver enzymes with biomarkers of subclinical myocardial damage and structural heart disease
Journal article   Open access   Peer reviewed

The association of liver enzymes with biomarkers of subclinical myocardial damage and structural heart disease

Mariana Lazo, Jonathan Rubin, Jeanne M. Clark, Josef Coresh, Andrea L.C. Schneider, Chiadi Ndumele, Ron C. Hoogeveen, Christie M. Ballantyne and Elizabeth Selvin
Journal of hepatology, v 62(4), pp 841-847
01 Apr 2015
DOI: https://doi.org/10.1016/j.jhep.2014.11.024
PMID: 25433159
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc4373587View
Accepted (AM)Open Access (License Unspecified),  Open
url
https://doi.org/10.1016/j.jhep.2014.11.024View
Published, Version of Record (VoR) Open

Abstract

NAFLD Natriuretic peptides Subclinical cardiac damage Troponin T
Patients with non-alcoholic fatty liver disease (NAFLD) are thought to be at increased risk of cardiovascular morbidity and mortality. However, the relationships between NAFLD and subclinical myocardial injury or structural heart disease are unknown. We conducted a cross-sectional analysis of 8668 participants from the Atherosclerosis Risk in Communities (ARIC) Study, who showed no clinical evidence of cardiovascular disease. We used levels of liver enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST] and gamma-glutamyl transpeptidase [GGT]), in the context of no history of elevated alcohol consumption as non-invasive surrogates of NAFLD. We used highly sensitive cardiac troponin T (hs-cTnT) and N-terminal pro-Brain natriuretic peptide (NT-proBNP) as biomarkers of myocardial damage and function. In this population-based study (mean age 63years, 60% women, 78% white), higher levels of ALT, AST, and GGT, even within the normal range, were significantly and independently associated with detectable (hs-cTnT >3ng/L) and elevated (hs-cTnT ⩾14ng/L) concentrations of hs-cTnT. The adjusted odds ratios (95% confidence interval) for elevated liver enzymes (vs. normal levels) with elevated hs-cTnT were: 1.65 (1.28–2.14) for ALT, 1.90 (1.36–2.68) for AST, and 1.55 (1.13–2.12) for GGT. Furthermore, there was evidence for inverse associations of ALT and AST with NT-proBNP. Our results suggest that elevated liver enzyme levels in the absence of elevated alcohol consumption may be associated with subclinical myocardial injury. The inverse association between NT-proBNP and both ALT and AST supports the recently described metabolic role of natriuretic peptides.

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Collaboration types
Domestic collaboration
Web of Science research areas
Gastroenterology & Hepatology
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