Journal article
The association of sex steroid hormone concentrations with non-alcoholic fatty liver disease and liver enzymes in US men
Liver international, v 41(2), pp 300-310
Feb 2021
PMID: 32860311
Abstract
This study aimed to analyse the association of sex hormone levels with liver enzyme levels and non-alcoholic fatty liver disease (NAFLD) in a nationally representative sample of men.
A total of 919 men from the US National Health and Nutrition Examination Study (NHANES) III were included in this cross-sectional analysis of data from 1988 to 1991. We used existing data on serum total and free testosterone, total and free estradiol, androstanediol glucuronide (AAG) and sex steroid-binding globulin (SHBG), and estimated their associations with aspartate aminotransferase (AST), and alanine aminotransferase (ALT) and NAFLD, as determined using ultrasound, after adjusting for possible confounders including age, race, smoking, alcohol, physical activity, waist circumference and steroid hormones.
Lower total testosterone (TT) and higher free estradiol were associated with higher odds of NAFLD after adjusting for confounders including the other sex hormones. Lower TT was associated with higher odds of elevated AST, but not ALT. Free testosterone, total estradiol, SHBG and AAG were not associated with NAFLD or liver enzymes.
This study supports an inverse association between TT concentration and NAFLD in men independent of other sex hormones (SHBG, AAG and estradiol) and known risk factors, such as obesity, age and lifestyle. Exploration of whether TT might be a non-invasive marker for NAFLD diagnosis is warranted.
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Details
- Title
- The association of sex steroid hormone concentrations with non-alcoholic fatty liver disease and liver enzymes in US men
- Creators
- Hong Phan - University of ZurichAline Richard - University of ZurichMariana Lazo - Johns Hopkins UniversityWilliam G Nelson - Johns Hopkins UniversitySamuel R Denmeade - Sidney Kimmel Comprehensive Cancer CenterJohn Groopman - Johns Hopkins UniversityNorma Kanarek - Johns Hopkins UniversityElizabeth A Platz - Johns Hopkins UniversitySabine Rohrmann - University of Zurich
- Publication Details
- Liver international, v 41(2), pp 300-310
- Grant note
- P30 CA006973 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Community Health and Prevention
- Web of Science ID
- WOS:000608550700008
- Scopus ID
- 2-s2.0-85099586061
- Other Identifier
- 991022171246604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Gastroenterology & Hepatology