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The bactericidal activity of magainins against Pseudomonas aeruginosa and Enterococcus faecium
Journal article   Peer reviewed

The bactericidal activity of magainins against Pseudomonas aeruginosa and Enterococcus faecium

Matthew E. Levison, Peter G. Pitsakis, Phyllis L. May and Caroline C. Johnson
Journal of antimicrobial chemotherapy, v 32(4), pp 577-585
Oct 1993
DOI: https://doi.org/10.1093/jac/32.4.577
PMID: 8288499
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

The antimicrobial activities of two synthetic magainins, MSI 94 and MSI 93, were investigated in vitro against 20 clinical isolates each of Pseudomonas aeruginosa and Enterococcus faecium. The ranges of the MICs of both agents were 6·25–50 mg/L for P. aeruginosa and 3·13–12·5 mg/L for E.faeciun. In time-kill studies, the magainins demonstrated rapid, concentration-dependent bactericidal activity against selected isolates of both species. This bactericidal effect was inoculum-dependent for P. aeruginosa in both the logarithmic and stationary phases of growth. Bacterial regrowth was regularly observed after 24 h of incubation in the time-kill studies; this was due to loss of antimicrobial activity during overnight incubation rather than to the development of resistance. More rapid and sustained bactericidal activity was noted when the magairuns were combined with either silver nitrate (AgNO3) or gentamicin against P. aeruginosa and with gentamicin against E. faecium. Neither agent produced a post-antibiotic effect on P. aeruginosa.

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Web of Science research areas
Infectious Diseases
Microbiology
Pharmacology & Pharmacy
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