Journal article
The biocompatibility of biodegradable glycine containing polyphosphazenes: A comparative study in bone
Journal of inorganic and organometallic polymers and materials, v 16(4), pp 387-396
01 Dec 2006
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Polyphosphazenes have gained considerable attention as biomaterials for use in tissue engineering and orthopaedic reconstruction. In this paper we examined the polyphosphazenes' in vivo biocompatibility and degradation by studying their ability to repair bone in a rabbit metaphyseal distal femur defect model. Matrices constructed from poly[(50% p-methylphenoxy)-(50%ethyl glycinato) phosphazene] (PPHOS-50) and poly[bis(ethyl glycinato) phosphazene] (PPHOS-100), were surgically implanted into a metaphyseal rabbit defect of the distal femur as constructs for tissue regeneration. Poly(lactide-co-glycolide) (PLAGA) implants, which are the biodegradable polymers most widely used clinically, and defects without polymers were used as controls in this experiment. Histological studies demonstrated that both PPHOS-50 and PPHOS-100 appeared to support bone growth comparable to the control PLAGA. By 12 weeks, femurs with polyphosphazene implants showed evidence of bone in-growth and a mild fibrous response. The PPHOS-50 implants were found to have a local tissue response that was more favorable than PPHOS-100 and similar to PLAGA. Biodegradable polyphosphazenes are a novel class of polymers which have been observed to facilitate bone growth in vivo.
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Details
- Title
- The biocompatibility of biodegradable glycine containing polyphosphazenes: A comparative study in bone
- Creators
- Saadiq F. El-Amin - University of VirginiaMichael S. Kwon - University of VirginiaTrevor Starnes - University of VirginiaHarry R. Allcock - Pennsylvania State UniversityCato T. Laurencin - University of Virginia
- Publication Details
- Journal of inorganic and organometallic polymers and materials, v 16(4), pp 387-396
- Publisher
- Springer Nature
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000244484100012
- Scopus ID
- 2-s2.0-33847404898
- Other Identifier
- 991021838565304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Polymer Science