Journal article
The biology of unconventional invasion of Duffy-negative reticulocytes byPlasmodium vivaxand its implication in malaria epidemiology and public health
Malaria journal, v 19(1), 299
24 Aug 2020
PMID: 32831093
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Plasmodium vivaxhas been largely neglected over the past century, despite a widespread recognition of its burden across region where it is endemic. The parasite invades reticulocytes, employing the interaction betweenPlasmodium vivaxDuffy binding protein (PvDBP) and human Duffy antigen receptor for chemokines (DARC). However,P. vivaxhas now been observed in Duffy-negative individuals, presenting a potentially serious public health problem as the majority of African populations are Duffy-negative. Invasion of Duffy-negative reticulocytes is suggested to be through duplication of the PvDBP and a novel protein encoded byP. vivaxerythrocyte binding protein (EBP) genes. The emergence and spread of specificP. vivaxstrains with ability to invade Duffy-negative reticulocytes has, therefore, drawn substantial attention and further complicated the epidemiology and public health implication of vivax malaria. Given the right environment and vectorial capacity for transmission coupled with the parasite's ability to invade Duffy-negative individuals,P. vivaxcould increase its epidemiological significance in Africa. In this review, authors present accruing knowledge on the paradigm shift inP. vivaxinvasion of Duffy-negative reticulocytes against the established mechanism of invading only Duffy-positive individuals and offer a perspective on the epidemiological diagnostic and public health implication in Africa.
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Details
- Title
- The biology of unconventional invasion of Duffy-negative reticulocytes byPlasmodium vivaxand its implication in malaria epidemiology and public health
- Creators
- Lemu Golassa - Addis Ababa UniversityLucas Amenga-Etego - University of GhanaEugenia Lo - University of North Carolina at CharlotteAlfred Amambua-Ngwa - MRC Unit the Gambia
- Publication Details
- Malaria journal, v 19(1), 299
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- African Academy of Sciences (AAS)'s Alliance for Accelerating Excellence in Science in Africa (AESA) UK government 107740/Z/15/Z / Wellcome Trust [DELGEME]; Wellcome Trust R15 A1138002 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 107740/Z/15/Z / DELTAS Africa Initiative [DELGEME] New Partnership for Africa's Development Planning and Coordinating Agency (NEPAD Agency); Norwegian Agency for Development Cooperation - NORAD
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000567103800001
- Other Identifier
- 991022192521104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Infectious Diseases
- Parasitology
- Tropical Medicine