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The blood pressure response to acute and chronic aerobic exercise: A meta-analysis of candidate gene association studies
Journal article   Peer reviewed

The blood pressure response to acute and chronic aerobic exercise: A meta-analysis of candidate gene association studies

Michael L. Bruneau, Blair T. Johnson, Tania B. Huedo-Medina, Kara A. Larson, Garrett I. Ash and Linda S. Pescatello
Journal of science and medicine in sport, v 19(5), pp 424-431
01 May 2016
DOI: https://doi.org/10.1016/j.jsams.2015.05.009
PMID: 26122461
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Life Sciences & Biomedicine Science & Technology Sport Sciences
Objectives: To meta-analyze candidate gene association studies on the change in blood pressure beyond the immediate post-exercise phase after versus before aerobic exercise. Design: Meta-analysis. Methods: A systematic search was conducted. Studies retrieved included acute (short-term or post-exercise hypotension) or chronic (long-term or training) aerobic exercise interventions; and blood pressure measured before and after aerobic exercise training, or before and after exercise or control under ambulatory conditions by genotype. Effect sizes were determined for genotype and adjusted for sample features. Results: Qualifying studies (k = 17, n=3524) on average included middle-aged, overweight men (44.2%) and women (55.8%) with prehypertension (134.9 +/- 11.7/78.6 +/- 9.5 mmHg). Training interventions (k = 12) were performed at 60.4 +/- 12.9% of maximum oxygen consumption (VO2max) for 41.9 +/- 12.5 min session(-1), 3.6 +/- 1.2 days week(-1) for 15.7 +/- 7.6 week; and post-exercise hypotension interventions (k = 5) were performed at 53.5 +/- 14.4% VO2max for 38.5 +/- 5.4 min session(-1). Sample characteristics explained 54.2-59.0% of the variability in the blood pressure change after versus before acute exercise or control under ambulatory conditions, and 57.4-67.1% of the variability in the blood pressure change after versus before training (p < 0.001). Only angiotensinogen M235T (rs699) associated with the change in diastolic blood pressure after versus before training (R-2 = 0.1%, p = 0.05), but this association did not remain statistically significant after adjustment for multiple comparisons. Conclusions: Sample characteristics explained most of the variability in the change of BP beyond the immediate post-exercise phase after versus before acute and chronic aerobic exercise. Angiotensinogen M235T (rs699) was the only genetic variant that associated with the change in diastolic blood pressure after versus before training, accounting for <1% of the variance. (C) 2015 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

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Sport Sciences
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