Journal article
The c- erbB transmembrane growth factor receptors as serum biomarkers in human cancer studies
Mutation research, v 333(1), pp 203-208
1995
PMID: 8538628
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Over-expression of the transmembrane growth factor receptors encoded by the c-
erbB oncogenes contributes to cellular transformation in model systems and is found to be a frequent occurrence in human tumors. Over-expression of these receptors results in accumulation of the extra-cellular domain in the extra-cellular supernatant in vitro and in elevated levels of the extra-cellular domain in serum in vivo in animal models. Similarly, elevated levels of the extra-cellular domain of these receptors have been detected in the serum of individuals with various cancers, including of the breast, ovary, prostate, stomach, pancreas, colon, liver, and lung. In some cases, elevated serum levels have been detectable prior to the time of clinical diagnosis of disease. Thus, the serum levels of the extra-cellular domains of the c-
erbB transmembrane growth factor receptors may be useful biomarkers of carcinogenesis in human studies.
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Details
- Title
- The c- erbB transmembrane growth factor receptors as serum biomarkers in human cancer studies
- Creators
- Paul W. Brandt-Rauf - Columbia University
- Publication Details
- Mutation research, v 333(1), pp 203-208
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:A1995TL83500023
- Scopus ID
- 2-s2.0-0029593312
- Other Identifier
- 991019323774704721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Genetics & Heredity
- Toxicology