Journal article
The cerebellar norepinephrine system: inhibition, modulation, and gating
Progress in brain research, v 88(C), pp 331-341
1991
PMID: 1687621
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A series of studies has been conducted to determine the mode of action on the cerebellar cortical circuitry of the norepinephrine (NE)-containing afferents from the locus coeruleus. NE has been known to exert an "inhibitory" action on the background firing observed in Purkinje cells, due presumably to a shift in conductances favoring hyperpolarization. An additional independent action at low threshold appears to be an enhancement of GABA, the inhibitory transmitter of cerebellar interneurons. Recent whole-cell patch-clamp studies on isolated Purkinje cells indicate that exposure to NE increases the chloride current caused by transient pulses of GABA applied iontophoretically. NE applied to Purkinje cells in the parafloccular lobule during stimulation by moving visual patterns revealed the capacity either to "gate" signals initially not expressed, or to amplify the gain of phasic excitations. The control of emergent circuit functions may be the functional consequence of the multiple modulatory functions of NE.
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Details
- Title
- The cerebellar norepinephrine system: inhibition, modulation, and gating
- Creators
- D J Woodward - The University of Texas Southwestern Medical CenterH C Moises - University of Michigan–Ann ArborB D Waterhouse - Hahnemann University HospitalH H Yeh - University of Rochester Medical CenterJ E Cheun - University of Rochester Medical Center
- Publication Details
- Progress in brain research, v 88(C), pp 331-341
- Publisher
- Elsevier
- Grant note
- AA-03901 / NIAAA NIH HHS DA-02338 / NIDA NIH HHS NS-24830 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1991BU87A00025
- Scopus ID
- 2-s2.0-0025789566
- Other Identifier
- 991019183970704721
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- Web of Science research areas
- Neurosciences