Journal article
The chromatographic separation of particles using optical electric fields
Lab on a chip, v 13(5), pp 928-939
01 Jan 2013
PMID: 23325461
Abstract
We introduce a new field-flow fractionation (FFF) technique, whereby molecules are separated based on their differential interaction (dielectrophoresis (DEP)) with optical electric fields, i.e. electric fields with frequencies in the visible and near-infrared range. The results show that a parallel array of axially non-uniform optical fields yielding an attractive potential (positive-DEP-FFF) is advantageous for the separation of polymers, biomolecules, and nanoparticles over very short distances. Furthermore, positive-DEP-FFF yields superior selectivity and resolution compared to conventional separation techniques, which do not lend themselves to miniaturization. A wide range of parameters are considered and the results are presented considering traditional chromatography parameters: the retention ratio and resolution. A simple analytical model is introduced which captures the trends for small normalized decay lengths and will be useful in the design of experimental separation platforms.
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Details
- Title
- The chromatographic separation of particles using optical electric fields
- Creators
- Nicolas Javier Alvarez - Technical University of DenmarkClaus Jeppesen - Technical University of DenmarkKresten Yvind - Technical University of DenmarkN. Asger Mortensen - Technical University of DenmarkOle Hassager - Technical University of Denmark
- Publication Details
- Lab on a chip, v 13(5), pp 928-939
- Publisher
- Royal Soc Chemistry
- Number of pages
- 12
- Grant note
- 10-082409 / Danish Council for Independent Research - Technology and Production Sciences; Det Frie Forskningsrad (DFF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000314651000022
- Scopus ID
- 2-s2.0-84875847732
- Other Identifier
- 991019292231104721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Chemistry, Analytical
- Chemistry, Multidisciplinary
- Instruments & Instrumentation
- Nanoscience & Nanotechnology