Journal article
The clinical electrophysiology of intravenous indecainide
The American heart journal, v 110(4), pp 784-788
1985
PMID: 4050649
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Abstract
The electrophysiologic effects of indecainide, a new class IC antiarrhythmic agent, were assessed in 10 patients with left ventricular dysfunction and inducible sustained ventricular tachycardia. Indecainide was administered intravenously in a dose of 60 to 90 mg/kg at a rate of 12.5 to 15 μg/kg/min. Indecainide had no effect on sinus node function or atrial and ventricular effective refractory periods. The AH (106 ± 13 vs 130 ± 24 msec,
p <0.002) and HV (57 ± 7 vs 73 ± 19 msec,
p <0.001) intervals were significantly increased. The QRS duration increased (102 ± 9 vs 120 ± 13 msec,
p<0.001); however, the JT duration did not change. Induction of ventricular tachycardia was prevented in 1 of 10 patients. In the remaining nine patients, the ventricular tachycardia cycle length was significantly prolonged (248 ± 47 vs 320 ± 71 msec,
p <0.001). Indecainide significantly depressed intracardiac conduction at several sites.
Metrics
Details
- Title
- The clinical electrophysiology of intravenous indecainide
- Creators
- Leonard N. Horowitz - Cardiovascular Institute of the SouthScott R. Spielman - Cardiovascular Institute of the SouthCharles R. Webb - Cardiovascular Institute of the SouthJoel Morganroth - Cardiovascular Institute of the SouthAllan M. Greenspan - Cardiovascular Institute of the South
- Publication Details
- The American heart journal, v 110(4), pp 784-788
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:A1985ASD7900011
- Scopus ID
- 2-s2.0-0022260137
- Other Identifier
- 991019339576304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems