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The complex aetiology of cerebral palsy
Journal article   Open access   Peer reviewed

The complex aetiology of cerebral palsy

Steven J Korzeniewski, Jaime Slaughter, Madeleine Lenski, Peterson Haak and Nigel Paneth
Nature reviews. Neurology, v 14(9), pp 528-543
01 Sep 2018
DOI: https://doi.org/10.1038/s41582-018-0043-6
PMID: 30104744
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1038/s41582-018-0043-6View
Published, Version of Record (VoR) Open

Abstract

Anticonvulsants - administration & dosage Cerebral Palsy - diagnosis Cerebral Palsy - epidemiology Cerebral Palsy - etiology Cerebral Palsy - prevention & control Child Congenital Abnormalities - epidemiology Female Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - etiology Humans Hypothermia, Induced - methods Infant, Newborn Infant, Premature, Diseases - epidemiology Infant, Premature, Diseases - etiology Magnesium Sulfate - administration & dosage Pregnancy Complications - epidemiology Pregnancy Complications - etiology Pregnancy
Cerebral palsy (CP) is the most prevalent, severe and costly motor disability of childhood. Consequently, CP is a public health priority for prevention, but its aetiology has proved complex. In this Review, we summarize the evidence for a decline in the birth prevalence of CP in some high-income nations, describe the epidemiological evidence for risk factors, such as preterm delivery and fetal growth restriction, genetics, pregnancy infection and other exposures, and discuss the success achieved so far in prevention through the use of magnesium sulfate in preterm labour and therapeutic hypothermia for birth-asphyxiated infants. We also consider the complexities of disentangling prenatal and perinatal influences, and of establishing subtypes of the disorder, with a view to accelerating the translation of evidence into the development of strategies for the prevention of CP.

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Domestic collaboration
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Clinical Neurology
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