Journal article
The course of moderate amblyopia treated with patching in children: Experience of the amblyopia treatment study
American journal of ophthalmology, v 136(4), pp 620-629
01 Oct 2003
PMID: 14516801
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
PURPOSE: To assess the course of the response to patching treatment of moderate amblyopia and to assess factors predictive of the response in children 3 years old to younger than 7 years old.
DESIGN: Multicenter, randomized clinical trial comparing patching and atropine (one of the amblyopia treatment studies).
METHODS: A total of 209 children 3 years old to younger than 7 years of age with amblyopia in the range of 20/40 to 20/100 from the patching treatment arm of this trial were treated with patching of the sound eye from 6 hours per day up to all waking hours. Follow,up examinations were performed at 5 weeks, 16 weeks, and 6 months. The primary outcome measure was visual acuity in the amblyopic eye at 6 months.
RESULTS: After 5 weeks of treatment, mean amblyopic ye acuity improved from baseline by 2.2 lines. For patients with baseline acuity of 20/80 or 20/100, a greater number of hours of prescribed patching was associated with greater improvement in the first 5 weeks (P = .05). However, this relationship was not present when baseline acuity was 20/40 to 20/60 (P = .57). At 6 months, visual acuity was improved from baseline by a mean of 3.1 lines, with the amount of improvement no longer related to the number of hours patching prescribed at baseline (P = .93). Among the 15 7 patients improving at least 3 lines from baseline, 15% achieved their maxi, mum improvement by 5 weeks and 52% by 16 weeks. None of the demographic or clinical factors assessed was predictive of the response to treatment.
CONCLUSIONS: In the treatment of moderate amblyopia, a beneficial effect of patching is present throughout the age range of 3 years old to younger than 7 years old and the acuity range of 20/40 to 20/100. At 6 months, the amount of improvement appears to be similar when 6 hours of daily patching are initially prescribed vs a greater number of hours. However, when the baseline acuity is 20/80 to 20/100, a greater number of hours of prescribed patching may improve acuity faster. (C) 2003 by Elsevier Inc. All rights reserved.
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Details
- Title
- The course of moderate amblyopia treated with patching in children: Experience of the amblyopia treatment study
- Creators
- R W HertleR W BeckE E BirchD L ChandlerR H DuckmanJ M HolmesJ D KivlinR T KrakerR J OlsonM X RepkaR P RutsteinR A SaundersPediat Eye Dis Investigator GrpMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- American journal of ophthalmology, v 136(4), pp 620-629
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- EY11751; U10 EY011751 / NEI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) U10EY011751 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000185538500004
- Scopus ID
- 2-s2.0-0141458940
- Other Identifier
- 991021900614804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Ophthalmology