Files and links (2)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair
eLife, v 10
04 Jun 2021
PMID: 34085927
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1(+) cells contribute to the development of meniscus horns from 2 weeks of age. In adult mice, Gli1(+) cells resided at the superficial layer of meniscus and expressed known mesenchymal progenitor markers. In culture, meniscal Gli1(+) cells possessed high progenitor activities under the control of Hh signal. Meniscus injury at the anterior horn induced a quick expansion of Gli1-lineage cells. Normally, meniscal tissue healed slowly, leading to cartilage degeneration. Ablation of Gli1(+) cells further hindered this repair process. Strikingly, intra-articular injection of Gli1(+) meniscal cells or an Hh agonist right after injury accelerated the bridging of the interrupted ends and attenuated signs of osteoarthritis. Taken together, our work identified a novel progenitor population in meniscus and proposes a new treatment for repairing injured meniscus and preventing osteoarthritis.
Metrics
Details
- Title
- The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair
- Creators
- Yulong Wei - University of PennsylvaniaHao Sun - Univ Penn, Perelman Sch Med, Dept Orthopaed Surg, Philadelphia, PA 19104 USATao Gui - Department of Bone and Joint Surgery, Institute of Orthopedic Diseases, The First Affiliated Hospital, Jinan University, Guangzhou, China.Lutian Yao - University of PennsylvaniaLeilei Zhong - University of PennsylvaniaWei Yu - Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Su-Jin Heo - University of PennsylvaniaLin Han - Drexel UniversityNathaniel A. Dyment - University of PennsylvaniaXiaowei Sherry Liu - University of PennsylvaniaYejia Zhang - University of PennsylvaniaEiki Koyama - Children's Hospital of PhiladelphiaFanxin Long - Children's Hospital of PhiladelphiaMiltiadis H. Zgonis - University of PennsylvaniaRobert L. Mauck - University of PennsylvaniaJaimo Ahn - University of PennsylvaniaLing Qin - University of Pennsylvania
- Publication Details
- eLife, v 10
- Publisher
- eLIFE SCIENCES PUBL LTD
- Number of pages
- 19
- Grant note
- R01AG067698; P30AR069619; CMMI-1751898 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000661027400001
- Scopus ID
- 2-s2.0-85107902294
- Other Identifier
- 991019168417704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biology