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The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?
Journal article   Open access   Peer reviewed

The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?

Peter D Katsikis, Yvonne M Mueller and François Villinger
PLoS pathogens, v 7(8), pp e1002055-e1002055
Aug 2011
DOI: https://doi.org/10.1371/journal.ppat.1002055
PMID: 21852945
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002055&type=printableView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1371/journal.ppat.1002055View
Published, Version of Record (VoR) Open

Abstract

Acute Disease AIDS Vaccines Animals Cytokines - drug effects Cytokines - physiology HIV Infections - physiopathology HIV Infections - prevention & control Humans Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - physiopathology Simian Immunodeficiency Virus Viral Load
Cytokines play a central role in the pathogenesis of many diseases, including HIV infection. However, the role of the cytokine network in early HIV infection is only now starting to be elucidated. A number of studies conducted in recent years have indicated that cytokines of the acute/early stages of HIV and SIV infection can impact viral set-point months later, and this is of critical importance since viral set-point during chronic HIV infection affects virus transmission and disease progression. This raises the question whether modulating the cytokine environment during acute/early HIV infection can be a target for novel approaches to develop a vaccine and therapeutics. In this review we focus on the kinetics and function of cytokines during acute HIV and SIV infection and how these may impact viral set-point. We also discuss unresolved questions that are essential for our understanding of the role of acute infection cytokines in HIV infection and that, if answered, may suggest novel therapeutic and vaccine strategies to control the worldwide HIV pandemic.

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11 Record Views
70 citations in Web of Science
71 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Microbiology
Parasitology
Virology
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