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The cytoskeletal arrangements necessary to neurogenesis
Journal article   Open access

The cytoskeletal arrangements necessary to neurogenesis

Claudia Compagnucci, Fiorella Piemonte, Antonella Sferra, Emanuela Piermarini and Enrico Bertini
Oncotarget, v 7(15), pp 19414-19429
12 Apr 2016
DOI: https://doi.org/10.18632/oncotarget.6838
PMID: 26760504
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.18632/oncotarget.6838View
Published, Version of Record (VoR) Open

Abstract

Cell Biology Life Sciences & Biomedicine Oncology Science & Technology
During the process of neurogenesis, the stem cell committed to the neuronal cell fate starts a series of molecular and morphological changes. The understanding of the physio-pathology of mechanisms controlling the molecular and morphological changes occurring during neuronal differentiation is fundamental to the development of effective therapies for many neurologic diseases. Unfortunately, our knowledge of the biological events occurring in the cell during neuronal differentiation is still poor. In this study, we focus preliminarily on the relevance of the cytoskeletal rearrangements, which earlier drive the morphology of the neuronal precursors, and later the migrating/mature neurons. In fact, neuritogenesis, neurite branching, outgrowth and retraction are seminal to the development of a fully functional nervous system. With this in mind, we highlight the importance of iPSC technology to study the processes of cytoskeletal-driven morphological changes during neuronal differentiation.

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38 citations in Web of Science
41 citations in Scopus

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Web of Science research areas
Cell Biology
Oncology
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