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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson’s Disease
Brain, behavior, and immunity, v 70, pp 21-35
May 2018
PMID: 29551693
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Peripheral immune cell functions are sensitive to dopamine regulation.•Some dopamine-regulated and other immune cell functions are dysregulated in PD.•DAT function controls dopaminergic tone and is associated with PD progression.•DAT is tightly regulated but peripheral DAT function is uncharacterized.•There is a potential bidirectional link between central and peripheral dopamine.
The second-most common neurodegenerative disease, Parkinson’s Disease (PD) has three hallmarks: dysfunctional dopamine transmission due, at least in part, to dopamine neuron degeneration; intracellular inclusions of α-synuclein aggregates; and neuroinflammation. The origin and interplay of these features remains a puzzle, as does the underlying mechanism of PD pathogenesis and progression. When viewed in the context of neuroimmunology, dopamine also plays a role in regulating peripheral immune cells. Intriguingly, plasma dopamine levels are altered in PD, suggesting collateral dysregulation of peripheral dopamine transmission. The dopamine transporter (DAT), the main regulator of dopaminergic tone in the CNS, is known to exist in lymphocytes and monocytes/macrophages, but little is known about peripheral DAT biology or how DAT regulates the dopaminergic tone, much less how peripheral DAT alters immune function. Our review is guided by the hypothesis that dysfunctional peripheral dopamine signaling might be linked to the dysfunctional immune responses in PD and thereby suggests a potential bidirectional communication between central and peripheral dopamine systems. This review seeks to foster new perspectives concerning PD pathogenesis and progression.
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Details
- Title
- The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson’s Disease
- Creators
- Phillip Mackie - Florida CollegeJoe Lebowitz - Florida CollegeLeila Saadatpour - Florida CollegeEmily Nickoloff - Drexel UniversityPeter Gaskill - Drexel UniversityHabibeh Khoshbouei - Florida College
- Publication Details
- Brain, behavior, and immunity, v 70, pp 21-35
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000433400900007
- Scopus ID
- 2-s2.0-85044155487
- Other Identifier
- 991019167821204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Neurosciences
- Psychiatry