Journal article
The dynamic pain connectome
Trends in neurosciences (Regular ed.), v 38(2), pp 86-95
01 Feb 2015
PMID: 25541287
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Traditionally, studies of how pain and attention modulate one another involved explicit cognitive-state manipulations. However, emerging evidence suggests that spontaneous brain-wide network communication is intrinsically dynamic on multiple timescales, and attentional states are in constant fluctuation. Here, in light of studies on neural mechanisms of spontaneous attentional fluctuations and pain variability, we introduce the concept of a dynamic 'pain connectome' in the brain. We describe how recent progress in our understanding of individual differences in intrinsic attention to pain and neural network dynamics in chronic pain can facilitate development of personalized pain therapies. Furthermore, we emphasize that the dynamics of pain-attention interactions must be accounted for in the contemporary search for a 'neural signature' of the pain connectome.
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Details
- Title
- The dynamic pain connectome
- Creators
- Aaron Kucyi - University Health NetworkKaren D. Davis - University Health Network
- Publication Details
- Trends in neurosciences (Regular ed.), v 38(2), pp 86-95
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Canadian Institutes of Health Research (CIHR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000349724300004
- Scopus ID
- 2-s2.0-84922916370
- Other Identifier
- 991021448154704721
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- Neurosciences