Journal article
The effect of Phe-Met-Arg-Phe-NH 2 (FMRFamide) on morphine-induced inhibition of colonic propulsive motility in mice
Neuroscience letters, v 83(1), pp 128-132
1987
Abstract
Morphine and the molluscan neuropeptide Phe-Met-Arg-Phe-NH
2 (FMRFamide) were administered to mice alone or in combination intracerebroventricularly (i.c.v.) and the effect on colonic propulsive motility was measured. Both morphine (1.0 μg, i.c.v.) and FMRFamide (10 and 50 μg, i.c.v.) delayed expulsion of a 3 mm glass bead placed in the distal colon of mice compared to vehicle-treated controls. The inhibitory effects of morphine and FMRFamide on expulsion time were additive at the doses used and individually blocked by naloxone. These data suggest that FMRFamide does not antagonize this non-analgesic effect of morphine, but appears to have opioid agonist properties.
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Details
- Title
- The effect of Phe-Met-Arg-Phe-NH 2 (FMRFamide) on morphine-induced inhibition of colonic propulsive motility in mice
- Creators
- Melissa B. JacobyHenry I. JacobyJoanne R. MathiasenRobert B. Raffa
- Publication Details
- Neuroscience letters, v 83(1), pp 128-132
- Publisher
- Elsevier Ireland Ltd; CLARE
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1987L183300023
- Scopus ID
- 2-s2.0-0023481857
- Other Identifier
- 991021900016004721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences