Journal article
The effect of charge regulation on cell adhesion to substrates: salt-induced repulsion
Colloids and surfaces, B, Biointerfaces, v 27(1)
2003
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The long-range forces controlling cell or bacteria adsorption onto substrates are governed by electrostatic interactions. In this paper we use a simple mean field model (Debye–Huckel) to examine the interactions between cells and surfaces. We model the cell interface as an ion-penetrable, charge-regulating layer, thereby accounting for the finite thickness of the cell's extra-cellular (glycocalyx) layer. We find that charge regulation leads to several non-intuitive trends regarding the repulsion between a cell and similarly charged substrates: (I) instead of increasing monotonically with decreasing cell–substrate separation, the pressure varies non-monotonically, and (II) instead of monotonically decreasing the repulsion (at contact) between the cell and the substrate, there is a regime where adding salt leads to an
increase in the repulsion.
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Details
- Title
- The effect of charge regulation on cell adhesion to substrates: salt-induced repulsion
- Creators
- Nily Dan - Drexel University
- Publication Details
- Colloids and surfaces, B, Biointerfaces, v 27(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000179955900005
- Scopus ID
- 2-s2.0-0037210367
- Other Identifier
- 991019312385804721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biophysics
- Chemistry, Physical
- Materials Science, Biomaterials