Journal article
The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial
Nutrition (Burbank, Los Angeles County, Calif.), v 99-100, 111674
Jul 2022
PMID: 35576873
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Improving magnesium and vitamin D status concomitantly in the overweight or obese population may lead to greater improvements in cardiometabolic outcomes than vitamin D supplements alone•Participants who received magnesium and vitamin D had a greater increase in serum 25-hydroxyvitamin D compared with participants in the vitamin D only group•There were no statistically significant effects of treatment on serum parathyroid hormone concentrations, markers of inflammation, and blood pressure between and within the groups•A combined magnesium and vitamin D treatment may be more effective in increasing serum 25-hydroxyvitamin D concentrations compared with vitamin D supplement alone in the overweight or obese population
Poor vitamin D and magnesium status is observed in individuals who are overweight and obese (Owt/Ob) and is often associated with a heightened risk of cardiovascular disease. Magnesium is a cofactor that assists vitamin D metabolism. We aimed to determine the efficacy of a combined magnesium and vitamin D regimen compared with vitamin D only on increasing serum 25-hydroxyvitamin D (25OHD) concentrations and the effects of these supplements on cardiometabolic outcomes.
This 12-week double-blinded randomized controlled trial had three treatment arms: magnesium + vitamin D (MagD; 360 mg magnesium glycinate + 1000 IU vitamin D 3 × daily), vitamin D only (VitD; 1000 IU vitamin D 3 × daily), and placebo. A total of 95 Owt/Ob participants were randomized into one of these three study arms. Anthropometry, dietary intake, concentrations of serum 25OHD, serum parathyroid hormone (PTH), serum inflammatory markers, and blood pressure were obtained at baseline and week 12.
The MagD group experienced the greatest increase in serum 25OHD concentrations (6.3 ± 8.36 ng/mL; P < 0.05). There was a decrease in systolic blood pressure (7.5 ± 8.26 mmHg; P < 0.05) for individuals who had a baseline systolic blood pressure of >132 mmHg in the MagD group. There were no statistically significant treatment effects on serum PTH concentrations and markers of inflammation.
A combined MagD treatment may be more effective in increasing serum 25OHD concentrations compared with VitD supplementation alone in Owt/Ob individuals.
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Details
- Title
- The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial
- Creators
- May M. Cheung - Monell Chemical Senses CenterRosemary D. Dall - Envision Pharma GroupPatricia A. Shewokis - Drexel UniversityAsma Altasan - King Saud bin Abdulaziz University for Health SciencesStella L. Volpe - Virginia TechRenee Amori - St. Luke's University Health NetworkHarpreet Singh - Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University College of MedicineDeeptha Sukumar - Drexel University College of Nursing and Health Professions
- Publication Details
- Nutrition (Burbank, Los Angeles County, Calif.), v 99-100, 111674
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nutrition Sciences
- Web of Science ID
- WOS:000806021000001
- Scopus ID
- 2-s2.0-85130390283
- Other Identifier
- 991019167873704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Nutrition & Dietetics
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